Pharmacology and Toxicology


Faculty List

Professors Emeriti
W.M. Burnham, PhD
D.M. Grant, PhD
T. Inaba, PhD
A.B. Okey, PhD
H. Orrego, PhD
C. Pace-Asciak, PhD
B.P. Schimmer, PhD
E.M. Sellers, MD, PhD

Professor and Chair of the Department
A. Salahpour, PhD, Interim Chair

Professors
R. Al-awar, PhD
M. Al-Omran, MD
A.C. Andreazza, PhD
B. Brands, PhD
D. Cherney, PhD
J. Daskalakis, PhD
V. De Luca, MD, PhD
P. Dorian, MD
J. Eubanks, PhD
Y. Finkelstein, MD
S. George, MD
B.I. Goldstein, MD, PhD
D. Haas, PhD, DDS
D.R. Hampson, PhD
S. Ito, MD
S. Kish, PhD
J. Kotsopoulos, PhD
K.L. Lanctôt, PhD
A.D. Lê, PhD
B. Le Foll, MD, PhD
G. Liu, MD, MSc
R.S. McIntyre, MD
J.H. Meyer, MD, PhD
J. Mitchell, PhD
D. Mueller, MD, PhD
J.N. Nobrega, PhD
M. Olson, PhD
K.S. Pang, PhD
J.D. Parker, MD
A. Petronis, MD, PhD
B. Pollock, MD
A. Ravindran, PhD
D. Riddick, PhD
R.A. Ross, PhD
P. Roy, PhD
J. Semple, PhD
E. Sibille, PhD
O.C. Snead III, MD
H.S. Sun, MD, PhD
R. Tyndale, PhD
J.P. Uetrecht, MD, PhD
S. Verma, MD, PhD
J.W. Wells, PhD
P.G. Wells, Pharm D
A.H.C. Wong, MD, PhD
M. Woo, MD, FRCPC, PhD
L.T. Young, MD, PhD

Professors, Teaching Stream
M.I. Arnot, PhD
C. Woodland, PhD

Associate Professors
M. Beaulieu, PhD
S. Belo, MD, PhD
L. Boileau, PhD
M. Hahn, MD, PhD, FRCPC
D. Hess, PhD
M.I. Husain, MD
B. Hubbard, PhD
S. Kloiber, MD
N. Kolla, MD, PhD, FRCPC, DABPN
J. Matthews, PhD
J.P. McPherson, PhD
R. Mizrahi, MD, PhD
A. Ortiz, MSc, MD
M. Piquette-Miller, PhD
A.J. Ramsey, PhD
A. Salahpour, PhD
L. Salmena, PhD
M. Schapira, PhD
J.A. Udell, MD, MPH
M. Vedadi, PhD
C. Wickens, PhD
R. Yanagawa, PhD, MPH
L. Zawertailo, PhD

Assistant Professors
M. Banasr, PhD
D. Barsyte-Lovejoy, PhD
P. Di Ciano, PhD
L. Edgar, PhD
L.C. Halabelian, PhD
R. Harding, PhD
A. Hassan, MD
M.I. Hussain, MBBS
N. Minian, PhD
N. Mittmann, PhD
V. Oliveira, PhD
M. Reed, PhD
K. Singh, PhD
M. Sloan, MD, MSc, FRCPC
W. Swardfager, PhD
H.W.H. Yu, PhD

Assistant Professors, Teaching Stream
A. Hamadanizadeh, PhD
P. Lala, PhD
A.J. Lança, MD, PhD
R. Laposa, PhD

Adjunct Professors
J.A. Arnot, PhD
G. Higgins, PhD
G. Kalabis, PhD
P.P. Li, PhD
J.M. Mayer, PhD
A. Nava-Ocampo, MSc, MD
M.G. Neuman, PhD
B. Pohlmann-Eden, MD, PhD
G. Rachamin, PhD
C. Toal, PhD
J. Wallace, PhD, MBA, FRSC
M. Zack, PhD

Adjunct Lecturers
J. Grant, PhD
A. Haller, PhD
M. Moller, MSc, MD
K. Nylen, PhD
J. Oldenhof, MSc, PhD
B. Setnik, PhD
M.J. Shram, PhD
D. Tambasco, MD

Introduction

Pharmacology and Toxicology are integrative biological sciences that examine the properties of chemical compounds and their interactions with living systems. They provide the scientific basis for the study of chemical actions in the health sciences, the use of drugs as therapeutic agents or as tools in scientific research, the development and control of pharmaceutical products, and the investigation and control of pollutants and poisons in natural and social environments. The Department of Pharmacology and Toxicology offers four Specialist and two Major undergraduate programs of study that are jointly sponsored by the Faculties of Arts and Science and Medicine. The Specialist programs have the added benefit of providing students with opportunities to learn advanced laboratory techniques and to gain real-world experience through supervised independent research projects and participation in the Arts & Science Internship Program (see below). Students who intend to pursue graduate research and/or careers in pharmacology or toxicology are encouraged to enrol in a Specialist program because of the opportunities for additional experiential learning.

Students wishing to enrol in the Biomedical Toxicology Specialist (ASSPE2573) or in the Pharmacology Specialist (ASSPE2082) will initially apply to the Joint Pharmacology and Biomedical Toxicology Specialist (ASSPE2340) at the end of their first year of study. Students wishing to enrol in the Biomedical Toxicology Major (ASMAJ2573) or in the Pharmacology Major (ASMAJ2082) will initially apply to a general departmental Major (ASMAJ2675) at the end of their first year of study and then select the focus for their future studies (Biomedical Toxicology or Pharmacology) prior to the start of the third year of study. Students wishing to enrol in the Environment and Toxicology Specialist (ASSPE0605) will apply directly to the program after completion of first year prerequisite courses. First and second year courses are the same for students within either the Specialist programs (ASSPE2082/​ ASSPE2340/​ ASSPE2573) or the Major programs (ASMAJ2675/ ASMAJ2082/ ASMAJ2573) within the Department. 

For further information about registration and courses, consult the Arts & Science Program Toolkit and Course Enrolment Instructions, and visit our website at: www.pharmtox.utoronto.ca.

Contact Information

Undergraduate Office - General Inquiries:
undergrad.pharmtox@utoronto.ca
Medical Sciences Building, Room 4207 (416-978-2728)

Associate Chair, Undergraduate Education:
Dr. M. Arnot
michelle.arnot@utoronto.ca
Medical Sciences Building, Room 4219 (416-978-3164)

 

Regarding Pharmacology and Toxicology Programs

Arts & Science Internship Program

Starting Fall 2021, the new Arts & Science Internship Program (ASIP) stream is available to students who are entering Year 2 or Year 3 of study and enrolled in the Biomedical Toxicology Specialist, Environment & Toxicology Specialist, Pharmacology Specialist, and the Specialist in Pharmacology and Biomedical Toxicology.

  • Enrolment is limited and requires a supplemental application. Students enrolled in the ASIP stream will be required to complete mandatory Professional Development programming plus a minimum of 12 and maximum of 20 months (Year 2 entry) or a minimum of 12 and maximum of 16 months (Year 3 entry) of paid, full-time work experience. The time to degree completion for students enrolled in ASIP will normally be 5 years. There is an additional cost to participate in the ASIP stream.
     
  • Students will typically be admitted to the ASIP stream for the Fall term of Year 2 of study, however, in exceptional circumstances students, including transfer students, who enrolled in an eligible program in the Summer after Year 2 can be admitted to the ASIP stream for the Fall of Year 3. Acceptance into an ASIP stream in Year 3 is dependent on space and requires approval of the student's academic unit and the Faculty of Arts & Science Experiential Learning & Outreach Support (ELOS) Office. Please refer to the ASIP eligibility page for further details.
     
  • Further details about ASIP, including eligibility requirements and application procedures, can be found here. Students may also visit the ASIP webpage or contact the ELOS office at asip@utoronto.ca.

Professional Experience Year Co-op

January 2022 was the last opportunity for Faculty of Arts & Science students to register for PEY Co-op. Students in Year 3 in the Fall/Winter 2021-2022 session were the last group of Faculty of Arts & Science students eligible to participate in PEY Co-op. Students starting Year 2 in Fall 2021 or later are only eligible to participate in the Arts & Science Internship Program stream.


NOTE

Students cannot combine any MAJOR or SPECIALIST from this program with another MAJOR or SPECIALIST from this program for their degree.

Pharmacology and Toxicology Programs

Biomedical Toxicology Specialist (Science Program) - ASSPE2573

Biomedical toxicology has emerged as an important science addressing drug safety and the adverse consequences of chemical exposure. The Biomedical Toxicology Specialist program examines the harmful effects of chemicals on the health and behaviour of individuals and society. The safety/toxicity of a wide array of chemicals is examined including pharmaceutical preparations, herbal products, natural toxins and environmental contaminants, with a focus on their effects on human health. This program emphasizes the application of toxicological knowledge and risk assessment and prepares students for a variety of job opportunities following its completion as well as for further study in graduate research or professional programs such as Medicine, Dentistry, and Pharmacy. (Note: Students interested in professional programs should contact the respective faculties to inquire about specific transfer credits.) Many graduates of the Biomedical Toxicology Specialist program pursue careers in scientific research, forensic science, nutrition and food sciences, governmental agencies, consulting agencies, and industrial settings including the pharmaceutical and chemical industries. Students learn about basic and clinical toxicology and related areas through lectures, tutorials, laboratories, and independent research projects. The senior research project course enables students to gain valuable research experience while working under the supervision of an individual faculty member in either a laboratory-based or a non-laboratory-based setting.

Enrolment Requirements:

This is a limited enrolment program. Students must have completed 8.0 credits and meet the requirements listed below to enroll. Students interested in this program should initially apply to the Specialist in Pharmacology & Biomedical Toxicology Program (ASSPE2340) after their first year of study. Students in ASSPE2340 will have the opportunity to move into the Biomedical Toxicology Specialist (ASSPE2573) following their second year of study.

Students who have completed 4.0 to 7.5 credits cannot apply directly to ASSPE2573 and must first apply to ASSPE2340, using the following courses:

Students who have completed at least 8.0 credits and who are already enrolled in ASSPE2340 may enrol in ASSPE2573 themselves on ACORN.

Students who have completed at least 8.0 credits but who are not already enrolled in ASSPE2340 must apply to ASSPE2573 using the following courses:


Variable Minimum Grade and Variable Minimum Grade Average
A minimum grade and minimum grade average in required courses are needed for entry, and this minimum changes each year depending on available spaces and the number of applicants.

To ensure that students admitted to the program will be successful, applicants with a final grade lower than 65% in any of these courses, or a combined grade average lower than 75% in these required courses will not be considered for admission. Please note that obtaining this minimum final grade and minimum grade average does not guarantee admission to the program.

Applications from students lacking numerical grades in one or more of the specified enrolment requirements, or students applying in their second or later years, may be considered on the basis of their entire academic record and the availability of space in the program. In addition to applying through ACORN, students applying in their second year or later are asked to please contact the department directly at undergrad.pharmtox@utoronto.ca, specify which program you would like to be considered for, and provide your student number. Please consult the Arts & Science Program Toolkit for more information on program enrolment.

Arts & Science Internship Program (ASIP)

Students in this program have the option to request enrolment in the Arts & Science Internship Program (ASIP) stream. Students can apply for the ASIP stream after Year 1 (Year 2 entry) or after Year 2 (Year 3 entry). Full details about ASIP, including student eligibility, selection and enrolment, are available in the ASIP section of the Arts & Science Academic Calendar. Please note that the majority of students enter ASIP in Fall term of Year 2. Space is more limited for Year 3 entry and there are program-specific year 3 entry enrolment requirements. Students applying for Year 3 entry must have been admitted to the Biomedical Toxicology Specialist in the Summer after Year 2 and completion of PCL201H1 (with a minimum grade of 77%), PSL300H1 and PSL301H1.

Notes:

  • While it is difficult to predict what will be competitive course marks and average in a given year, based on previous years, the estimate is: course marks = mid 80s; average = mid 80s.
  • Students wishing to enroll in the Biomedical Toxicology Specialist will initially apply to the Joint Specialist in Pharmacology and Biomedical Toxicology (ASSPE2340). After admission, students can then choose to transfer to the Biomedical Toxicology Specialist. First and second year courses are the same for all Specialist programs within the Department (ASSPE2082/ASSPE2340/ASSPE2573).
  • Students cannot combine the Biomedical Toxicology Specialist with either departmental Major programs (Biomedical Toxicology or Pharmacology).
  • Students wishing to enroll after their second year who have taken PCL201H1 will be considered on a case by case basis. Successful completion of pre-requisite courses is required to enroll in upper level program courses. Students may not transfer to the Major program from the Specialist after completion of PCL474Y1 or INT300H1/​ INT301H1 in the Arts & Science Internship Program (ASIP).
Completion Requirements:

(14.0 credits)

First Year: BIO120H1, BIO130H1, ( CHM135H1, CHM136H1)/ CHM151Y1, and 1.0 credit from any combination of ( MAT135H1, MAT136H1)/ MAT137Y1/​ MAT157Y1, PHY131H1/​ PHY151H1, PHY132H1/​ PHY152H1 (see NOTE 1)

Students in this program have the option to enrol in the Arts & Science Internship Program (ASIP) stream.

Second Year: BCH210H1, BIO230H1/​ BIO255H1, BIO260H1/​ HMB265H1, CHM247H1/​ CHM249H1, STA288H1, PCL201H1, ( PSL300H1, PSL301H1) (NOTE: PSL201Y1 is not acceptable)

Third Year: PCL302H1, PCL381H1, at least one 0.5 credit from PCL367H1 or PCL368H1

Third or Fourth Year: LMP363H1 and 2.5 credits at least 1.5 credits from PCL courses: JPM300H1/​ PCL345H1/​ PCL362H1 / PCL367H1 or PCL368H1 (see NOTE 2)/ PCL386H1/​ PCL389H1/​ PCL475H1/​ PCL476H1/​ PCL477H1/​ PCL484H1/​ PCL490H1/​ JPM400Y1/​ ANA301H1/​ CHM310H1/​ ESS463H1/​ LMP301H1

Fourth Year: PCL402H1, ( PCL482H1, PCL483H1), PCL474Y1/​ JPM400Y1 (see NOTE 3)

An Integrative, Inquiry-Based Activity Requirement must be satisfied.

The requirement for an integrative, inquiry-based and/or experiential activity must be met by completing at least one of the following: PCL297H1, PCL389H1, PCL397Y0, PCL474Y1, JPM400Y1. Students who complete the Arts & Science Internship Program (ASIP) stream will also meet this requirement.

NOTES:

  1. Any PHY/MAT courses should be completed during the first year and included for program enrolment.
  2. At least 0.5 credit from PCL367H1 or PCL368H1 is required for the program, however if desired the alternative course can be taken as a program elective.
  3. Enrolment in any of PCL474Y1 or JPM400Y1 is limited and requires permission from the Department of Pharmacology and Toxicology. Students must receive prior consent from the course coordinator according to Departmental guidelines before the Department will register them in the course. Students can take either course as their required independent project, or may take JPM400Y1 as an additional elective. It is the student’s responsibility to make all necessary preparations before the session starts (see course description).
  4. Students wishing to apply their Arts & Science Internship Program (ASIP) towards the requirement to complete PCL474Y1/​ JPM400Y1 should reach out to undergrad.pharmtox@utoronto.ca.

Environment & Toxicology Specialist (Science Program) - ASSPE0605

This program is jointly sponsored by the Department of Pharmacology and Toxicology and the School of the Environment. For additional information see “School of the Environment” (www.environment.utoronto.ca) or consult our website: www.pharmtox.utoronto.ca.

The Environment and Toxicology Specialist program is an interdisciplinary program which spans the social, physical and life sciences and integrates study of the effects of chemicals not only on the health and behaviour of human beings but on whole ecosystems as the adverse effects associated with therapeutic and environmental chemicals are discussed. This program emphasizes the application of knowledge of environmental toxicology and risk assessment and prepares students for a variety of job opportunities following its completion. Graduates of the Environment and Toxicology program may pursue careers in scientific research, environmental science, conservation science, governmental agencies, consulting agencies, and within chemical, manufacturing or agriculture industries. Students learn to integrate basic environmental and life science with particular aspects of clinical toxicology and related areas through lectures, tutorials, and laboratory and independent research project experience. The senior independent research project course enables students to gain valuable research experience while working under the supervision of an individual faculty member in either a laboratory-based or a non-laboratory-based setting.

Enrolment Requirements:

This is a limited enrolment program. Students must have completed 4.0 credits and meet the requirements listed below to enroll.

Variable Minimum Grade Average
A minimum grade average in required courses is needed for entry, and this minimum changes each year depending on available spaces and the number of applicants. The following courses or their equivalents must be completed:

To ensure that students admitted to the program will be successful, applicants with a final grade lower than 65% in each course, or a combined grade average lower than 70% in these required courses will not be considered for admission. Please note that obtaining this minimum final grade or minimum grade average does not guarantee admission to the program. The underlying numeric final mark in each of your courses required for program enrolment will be used by the relevant academic unit to determine your eligibility.

Applications from students lacking numerical grades in one or more of the specified prerequisites, or students applying in their second or later years, may be considered on the basis of their entire academic record and the availability of space in the program. In addition to applying through ACORN, students applying in their second year or later are asked to please contact the department directly at undergrad.pharmtox@utoronto.ca, specify which program you would like to be considered for, and provide your student number. Please consult the Arts & Science Program Toolkit for more information on program enrolment.

Arts & Science Internship Program (ASIP)

Students in this program have the option to request enrolment in the Arts & Science Internship Program (ASIP) stream. Students can apply for the ASIP stream after Year 1 (Year 2 entry) or after Year 2 (Year 3 entry, starting Fall 2024). Full details about ASIP, including student eligibility, selection and enrolment, are available in the ASIP section of the Arts & Science Academic Calendar. Please note that the majority of students enter ASIP in Fall term of Year 2. Space is more limited for Year 3 entry and there are program-specific year 3 entry enrolment requirements. Students applying for Year 3 entry must have been admitted to the Environment & Toxicology Specialist in the Summer after Year 2 and completion of PCL201H1 (with a minimum grade of 77%), PSL300H1 and PSL301H1.

Notes:

  • The Environment and Toxicology Specialist cannot be combined with the Biomedical Toxicology Major or the Pharmacology Major.
  • Students who wish to enroll in the program after their second year will be considered on a case-by-case basis. Successful completion of required prerequisite courses is required to enroll in further upper-level program courses.
Completion Requirements:

(14.0 credits, including 4.0 credits at the 300+level, 1.0 credit of which must be at the 400-level).

First Year: BIO120H1, BIO130H1, ( CHM135H1, CHM136H1)/ CHM151Y1, and at least 1.0 credit from MAT135H1, MAT136H1, MAT137Y1, MAT157Y1, PHY131H1, PHY132H1, PHY151H1, PHY152H1

Students in this program have the option to enrol in the Arts & Science Internship Program (ASIP) stream.

Second Year: BCH210H1, BIO230H1/​ BIO255H1, ENV221H1, ENV222H1, PCL201H1 and CHM247H1. 1.0 credit from ( BIO270H1, BIO271H1)/ ( PSL300H1, PSL301H1) (see NOTE 1)

Third and Fourth Years:

BIO220H1, EEB240H1, JGE321H1, CHM210H1, PCL302H1, PCL381H1, PCL482H1, PCL483H1

One of: ENV341H1/​ ENV337H1/​ EEB320H1
One of: STA220H1/​ STA221H1/​ STA288H1/​ EEB225H1 (see NOTE 2)
One of: ENV421Y1/​ PCL367H1/​ PCL474Y1 (see NOTE 2)
At least 1.0 credit from: EEB321H1, EEB365H1, EEB428H1, ENV462H1, PHY231H1, CHM310H1, JPM300H1, PCL362H1, PCL386H1, PCL477H1, PCL484H1, PCL490H1, LMP301H1, LMP363H1 (see NOTE 3)

An Integrative, Inquiry-Based Activity Requirement must be satisfied.

The requirement for an integrative, inquiry-based and/or experiential activity must be met by completing at least one of the following: PCL297H1, PCL367H1, PCL397Y0, ENV421H1, ENV421Y1, PCL474Y1. Students who complete the Arts & Science Internship Program (ASIP) stream or PEY Co-op will also meet this requirement.

Note: January 2022 was the last opportunity for Faculty of Arts & Science students to register for PEY Co-op. Students in Year 3 in the Fall/Winter 2021-2022 were the last group of Faculty of Arts & Science students eligible to participate in PEY Co-op. Students starting Year 2 in Fall 2021 or later are only eligible to participate in the Arts & Science Internship Program stream.

Notes:

  1. PSL300H1 and PSL301H1 require MAT 100-level/ PHY 100-level courses.
  2. PCL201H1, PCL302H1, and PCL367H1 are pre-requisites for students intending to take PCL474Y1. Students intending to take PCL474Y1 must obtain permission from the Undergraduate Student Advisor of the School of the Environment 3 months prior to the intended date of enrolment. Students must also consult with the Department of Pharmacology and Toxicology at least 3 months prior to the intended date of enrolment. Students wishing to take ENV421Y1 are advised to take the course during third year, due to scheduling conflicts with fourth year requirements.
  3. Students taking PCL477H1 must take BCH210H1 prior. Students taking only PCL367H1 must take 1.5 credits from program electives requirement list of courses to ensure 14.0 program credits. Students may choose to take both PCL367H1 and ENV421Y1/​ PCL474Y1 and would then need to take only 0.5 credits from the program electives requirement list of courses to ensure 14.0 program credits.

Pharmacology Specialist (Science Program) - ASSPE2082

Pharmacology is an integrative medical science that builds upon the core foundational disciplines of the basic life sciences. The Pharmacology Specialist program aims to provide students with an understanding of the therapeutic properties and clinical uses of externally administered chemical substances in the whole body, as well as the mechanisms of their actions and interactions with molecular, cellular and tissue targets. This understanding prepares students for a variety of either research-based or non-research-based careers, including positions in the pharmaceutical and biotechnology industries, in government agencies, in research institutes and in universities. Students learn about both basic and clinical pharmacology through lectures, tutorials, laboratories and independent research projects. The senior research project course enables students to gain valuable research experience while working under the supervision of an individual faculty member in either a laboratory-based or a non-laboratory-based setting.

Pharmacology (and its application in clinical therapeutics) plays a prominent role in society, and a comprehension of drug mechanisms and uses is fundamental to career success in the fields of medicine, dentistry, pharmacy and nursing. While some students take the Pharmacology Specialist program in preparation for these professional programs, students are advised to contact the respective Faculties directly for questions related to transfer credits.

Enrolment Requirements:

This is a limited enrolment program. Students must have completed 8.0 credits and meet the requirements listed below to enroll. Students interested in this program should initially apply to the Specialist in Pharmacology & Biomedical Toxicology Program (ASSPE2340) after their first year of study. Students in ASSPE2340 will have the opportunity to move into the Pharmacology Specialist (ASSPE2082) following their second year of study.

Students who have completed 4.0 to 7.5 credits cannot apply directly to ASSPE2082 and must first apply to ASSPE2340, using the following courses:

Students who have completed at least 8.0 credits and who are already enrolled in ASSPE2340 may enrol in ASSPE2082 themselves on ACORN.

Students who have completed at least 8.0 credits but who are not already enrolled in ASSPE2340 must apply to ASSPE2082 using the following courses:

Variable Minimum Grade and Variable Minimum Grade Average
A minimum grade and minimum grade average in required courses are needed for entry, and this minimum changes each year depending on available spaces and the number of applicants.

To ensure that students admitted to the program will be successful, applicants with a final grade lower than 65% in each course, or a combined grade average lower than 75% in these required courses will not be considered for admission. Please note that obtaining this minimum final grade and minimum grade average does not guarantee admission to the program. The underlying numeric final mark in each of your courses required for program enrolment will be used by the relevant academic unit to determine your eligibility.

Applications from students lacking numerical grades in one or more of the specified enrolment requirements, or students applying in their second or later years, may be considered on the basis of their entire academic record and the availability of space in the program. In addition to applying through ACORN, students applying in their second year or later are asked to please contact the department directly at undergrad.pharmtox@utoronto.ca, specify which program you would like to be considered for, and provide your student number. Please consult the Arts & Science Program Toolkit for more information on program enrolment.

Arts & Science Internship Program (ASIP)

Students in this program have the option to request enrolment in the Arts & Science Internship Program (ASIP) stream. Students can apply for the ASIP stream after Year 1 (Year 2 entry) or after Year 2 (Year 3 entry, starting Fall 2024). Full details about ASIP, including student eligibility, selection and enrolment, are available in the ASIP section of the Arts & Science Academic Calendar. Please note that the majority of students enter ASIP in Fall term of Year 2. Space is more limited for Year 3 entry and there are program-specific year 3 entry enrolment requirements. Students applying for Year 3 entry must have been admitted to the Pharmacology Specialist in the Summer after Year 2 and completion of PCL201H1 (with a minimum grade of 77%), PSL300H1 and PSL301H1.

Notes:

  • While it is difficult to predict what will be competitive course marks and average in a given year, based on previous years, the estimate is: course marks = mid 80s; average = mid 80s.
  • Students wishing to enroll in the Pharmacology Specialist will initially apply to the Joint Specialist in Pharmacology and Biomedical Toxicology (ASSPE2340). After admission, students can then choose to transfer to the Biomedical Toxicology Specialist. First and second year courses are the same for all Specialist programs within the Department (ASSPE2082/ASSPE2340/ASSPE2573).
  • Students cannot combine the Biomedical Toxicology Specialist with either departmental Major programs (Biomedical Toxicology or Pharmacology).
  • Students wishing to enroll after their second year who have taken PCL201H1 will be considered on a case by case basis. Successful completion of required pre-requisite courses is required to further enroll in upper level program courses. Students may not transfer to the Major program from the Specialist after completion of PCL472Y1 or INT300H1/​ INT301H1 in the Arts & Science Internship Program (ASIP).
Completion Requirements:

(14.5 credits)

First Year: BIO120H1, BIO130H1, ( CHM135H1, CHM136H1)/ CHM151Y1, and 1.0 credit from any combination of ( MAT135H1, MAT136H1)/ MAT137Y1/​ MAT157Y1, PHY131H1/​ PHY151H1, PHY132H1/​ PHY152H1 (see NOTE 1)

Students in this program have the option to enrol in the Arts & Science Internship Program (ASIP) stream.

Second Year: BCH210H1, BIO230H1/​ BIO255H1, BIO260H1/​ HMB265H1, CHM247H1/​ CHM249H1, STA288H1, PCL201H1, ( PSL300H1, PSL301H1) (NOTE: PSL201Y1 is not acceptable)

Third Year: BCH311H1/​ PSL350H1, PCL302H1, at least one 0.5 credit from PCL367H1 or PCL368H1

Third or Fourth Year: PCL469H1 and 3.5 credits with at least 1.5 credits from PCL courses: JPM300H1/​ PCL345H1/​ PCL367H1 or PCL368H1 (see NOTE 2)/ PCL386H1/​ PCL389H1/​ PCL475H1/​ PCL476H1/​ PCL477H1/​ PCL484H1/​ PCL490H1/​ JPM400Y1/​ ANA300Y1/​ BCH340H1/​ BCH450H1

Fourth Year: PCL402H1, PCL470H1, PCL472Y1/​ JPM400Y1 (see NOTE 3)

An Integrative, Inquiry-Based Activity Requirement must be satisfied.

The requirement for an integrative, inquiry-based and/or experiential activity must be met by completing at least one of the following: PCL297H1, PCL389H1, PCL397Y0, PCL472Y1, JPM400Y1. Students who complete the Arts & Science Internship Program (ASIP) stream will also meet this requirement.

NOTES:

  1. Any PHY/MAT courses should be completed during the first year and included for program enrolment.
  2. At least one 0.5 credit from PCL367H1 or PCL368H1 is required for the program, however if desired the alternative course can be taken as a program elective.
  3. Enrolment in either PCL472Y1 or JPM400Y1 is limited and requires permission from the Department of Pharmacology and Toxicology. Students must receive prior consent from course coordinator according to Departmental guidelines before the Department will register them in the course. Students can take either course as their required independent project, or may take JPM400Y1 as an additional elective. It is the student’s responsibility to make all necessary preparations before the session starts (see course description).
  4. Students wishing to apply their Arts & Science Internship Program (ASIP) towards the requirement to complete PCL472Y1/​ JPM400Y1 should reach out to undergrad.pharmtox@utoronto.ca.

Specialist in Pharmacology and Biomedical Toxicology (Science Program) - ASSPE2340

Pharmacology and Biomedical Toxicology are complementary sciences, and the Pharmacology and Biomedical Toxicology Specialist combines the requirements of the two distinct specialist programs. The Specialist program integrates knowledge of pharmacology – the understanding of the therapeutic properties and clinical applications of externally administered chemical substances in the whole body and the mechanisms of their actions and interactions with their intended targets, while biomedical toxicology examines the harmful effects of exogenous chemicals on the health and behaviour of individuals and society, addressing drug safety and the adverse consequences of chemical exposure. Biomedical toxicology includes understanding the safety/toxicity of a wide array of chemicals (pharmaceutical preparations, herbal products, natural toxins and environmental contaminants) with a focus on their effects and adverse consequences on human health.

Both Pharmacology and Biomedical Toxicology are integrative life sciences which build on the core foundational disciplines of the basic life sciences and the prominent role each science plays in society. A comprehension of the biological mechanisms of action and potential uses of chemicals are key to career success in the fields of medicine, dentistry, pharmacy and nursing. The Specialist program prepares students for a variety of job opportunities following its completion as well as for further study in graduate research or professional programs such as Medicine, Dentistry, and Pharmacy. (Note: Students interested in professional programs should contact the respective faculties to inquire about specific transfer credits.) Graduates of this rigorous program will have access to an impressive variety of job opportunities in either research-based or non-research-based careers, including scientific research in research institutes and in universities, positions in the pharmaceutical, biotechnology and chemical industries, forensic science, nutrition and food sciences, government or consulting agencies. Students learn about both basic and clinical pharmacology and biomedical toxicology through lectures, tutorials, small group sessions, laboratories and independent research projects. The senior research project course enables students to gain valuable research experience while working under the supervision of an individual faculty member in either a laboratory-based or a non-laboratory-based setting.

Enrolment Requirements:

This is a limited enrolment program. Students must have completed 4.0 credits and meet the requirements listed below to enrol.

Variable Minimum Grade or Variable Minimum Grade Average
A minimum grade/minimum grade average in required courses is needed for entry, and this minimum changes each year depending on available spaces and the number of applicants. The following courses or their equivalents must be completed:

Students who have completed 4.0 to 7.5 credits can apply directly to ASSPE2340 using the following courses:

Students who have completed at least 8.0 credits and who are already enrolled in ASSPE2340 have the option of remaining in the program until completion or may enrol themselves in ASSPE2082 or ASSPE2573 on ACORN.

Students who have completed at least 8.0 credits but who are not already enrolled in ASSPE2340 must apply using the following courses:

To ensure that students admitted to the program will be successful, applicants with a final grade lower than 65% in each course, or a combined grade average lower than 75% in these required courses will not be considered for admission. Please note that obtaining this minimum final grade or minimum grade average does not guarantee admission to the program. The underlying numeric final mark in each of your courses required for program enrolment will be used by the relevant academic unit to determine your eligibility.

Applications from students lacking numerical grades in one or more of the specified prerequisites, or students applying in their second or later years, may be considered on the basis of their entire academic record and the availability of space in the program. In addition to applying through ACORN, students applying in their second year or later are asked to please contact the department directly at undergrad.pharmtox@utoronto.ca, specify which program you would like to be considered for, and provide your student number. Please consult the Arts & Science Program Toolkit for more information on program enrolment.

Arts & Science Internship Program (ASIP)

Students in this program have the option to request enrolment in the Arts & Science Internship Program (ASIP) stream. Students can apply for the ASIP stream after Year 1 (Year 2 entry) or after Year 2 (Year 3 entry, starting Fall 2024). Full details about ASIP, including student eligibility, selection and enrolment, are available in the ASIP section of the Arts & Science Academic Calendar. Please note that the majority of students enter ASIP in Fall term of Year 2. Space is more limited for Year 3 entry and there are program-specific year 3 entry enrolment requirements. Students applying for Year 3 entry must have been admitted to the Specialist in Pharmacology and Biomedical Toxicology in the Summer after Year 2 and completion of PCL201H1 (with a minimum grade of 77%), PSL300H1 and PSL301H1.

Notes:

  • While it is difficult to predict what will be competitive course marks and average in a given year, based on previous years, the estimate is: course marks = mid 80s; average = mid 80s.
  • Students wishing to enroll in the Pharmacology Specialist (ASSPE2082) or Biomedical Toxicology Specialist (ASSPE2573) will initially apply to the Joint Specialist in Pharmacology and Biomedical Toxicology (ASSPE2340). After admission, students can then choose to transfer to the Biomedical Toxicology Specialist. First and second year courses are the same for all Specialist programs within the Department (ASSPE2082/ASSPE2340/ASSPE2573).
  • Students cannot combine the Pharmacology and Biomedical Toxicology Specialist with either departmental Major programs (Biomedical Toxicology or Pharmacology).
  • Students wishing to enroll after their second year who have taken PCL201H1 will be considered on a case by case basis. Successful completion of required pre-requisite courses is required to further enroll in upper level program courses. Students may not transfer to the Major program from the Specialist after completion of PCL472Y1/​ PCL474Y1 courses or INT300H1/​ INT301H1 in the Arts & Science Internship Program (ASIP).
Completion Requirements:

(14.5 credits)

First Year: BIO120H1, BIO130H1, ( CHM135H1, CHM136H1)/ CHM151Y1, and 1.0 credit from any combination of ( MAT135H1, MAT136H1)/ MAT137Y1/​ MAT157Y1, PHY131H1/​ PHY151H1, PHY132H1/​ PHY152H1 (see NOTE 1)

Students in this program have the option to enrol in the Arts & Science Internship Program (ASIP) stream.

Second Year: BCH210H1, BIO230H1/​ BIO255H1, BIO260H1/​ HMB265H1, CHM247H1/​ CHM249H1, STA288H1, PCL201H1, ( PSL300H1, PSL301H1) (NOTE: PSL201Y1 is not acceptable)

Third Year: BCH311H1/​ PSL350H1, PCL302H1, PCL381H1, at least one 0.5 credit from PCL367H1 or PCL368H1 (see NOTE 2)

Third or Fourth Year: LMP363H1, PCL469H1, and 1.5 credits from the following courses: JPM300H1/​ PCL345H1/​ PCL362H1 / PCL367H1 or PCL368H1 (see NOTE 2)/ PCL386H1/​ PCL389H1/​ PCL475H1/​ PCL476H1/​ PCL477H1/​ PCL484H1/​ PCL490H1/​ JPM400Y1/​ LMP301H1. Additional courses that may strengthen your background in this program can be taken, but will not count towards your program: ANA300Y1/​ ANA301H1/​ BCH340H1/​ CHM310H1/​ ESS463H1

Fourth Year: PCL402H1; PCL470H1; ( PCL482H1, PCL483H1); PCL472Y1/​ PCL474Y1/​ JPM400Y1 (see NOTE 3)

An Integrative, Inquiry-Based Activity Requirement must be satisfied.

The requirement for an integrative, inquiry-based and/or experiential activity must be met by completing at least one of the following: PCL297H1, PCL389H1, PCL397Y0, PCL472Y1, PCL474Y1, JPM400Y1. Students who complete the Arts & Science Internship Program (ASIP) will also meet this requirement.

NOTES:

  1. Any PHY/MAT courses should be completed during the first year and included for program enrolment.
  2. At least one 0.5 credit from PCL367H1 or PCL368H1 is required for the program, however if desired the alternative course can be taken as a program elective.
  3. Enrolment in any of PCL472Y1/​ PCL474Y1 or JPM400Y1 is limited and requires permission from the Department of Pharmacology and Toxicology. Students must receive prior consent from the course coordinator according to Departmental guidelines before the Department will register them in the course. Students can take either course as their required independent project, or may take JPM400Y1 as an additional elective. It is the student’s responsibility to make all necessary preparations before the session starts (see course description).
  4. Students wishing to apply their Arts & Science Internship Program (ASIP) towards the requirement to complete PCL472Y1/​ PCL474Y1/​ JPM400Y1 should reach out to undergrad.pharmtox@utoronto.ca.

Biomedical Toxicology Major (Science Program) - ASMAJ2573

Biomedical toxicology has emerged as an important science addressing drug safety and the adverse consequences of chemical exposure. The Biomedical Toxicology Major program examines the harmful effects of chemicals on the health and behavior of individuals and society. The safety/toxicity of a wide array of chemicals is examined including pharmaceutical preparations, herbal products, natural toxins, and environmental contaminants, with a focus on their effects on human health. Students learn about basic and clinical toxicology and related areas through lectures, tutorials and class discussions/debates.

This program includes the application of toxicological knowledge and risk assessment and prepares students for a variety of job opportunities following its completion as well as for further study in graduate research or professional programs such as Medicine, Dentistry, and Pharmacy. (Note: Students interested in professional programs should contact the respective faculties to inquire about specific transfer credits.) Many graduates of the Biomedical Toxicology major program pursue careers in scientific research, forensic science, nutrition and food sciences, governmental agencies, consulting agencies, and industrial settings including the pharmaceutical and chemical industries.

Enrolment Requirements:

This is a limited enrolment program. Students must have completed 8.0 credits and meet the requirements listed below to enroll. Students interested in this program should initially apply to the general Major (ASMAJ2675) after their first year of study. Following their second year of study, students in ASMAJ2675 must choose to pursue either the Pharmacology Major (ASMAJ2082) or the Biomedical Toxicology Major (ASMAJ2573).

Students who have completed 4.0 to 7.5 credits cannot apply directly to ASMAJ2573 and must first apply to ASMAJ2675, using the following courses:

Students who have completed at least 8.0 credits and who are already enrolled in ASMAJ2675 may enrol in ASMAJ2573 themselves on ACORN.

Students who have completed at least 8.0 credits but who are not already enrolled in ASMAJ2675 must apply to ASMAJ2573 using the following courses:


Variable Minimum Grade or Variable Minimum Grade Average
A minimum grade and minimum grade average in required courses are needed for entry, and this minimum changes each year depending on available spaces and the number of applicants.

To ensure that students admitted to the program will be successful, applicants with a final grade lower than 65% in any of these courses, or a combined grade average lower than 70% in these required courses will not be considered for admission. Please note that obtaining this minimum final grade and minimum grade average does not guarantee admission to the program.

Applications from students lacking numerical grades in one or more of the specified enrolment requirements, or students applying in their second or later years, may be considered on the basis of their entire academic record and the availability of space in the program. In addition to applying through ACORN, students applying in their second year or later are asked to please contact the department directly at undergrad.pharmtox@utoronto.ca, specify which program you would like to be considered for, and provide your student number. Please consult the Arts & Science Program Toolkit for more information on program enrolment.

Notes:

  • While it is difficult to predict what will be competitive course marks and average in a given year, based on previous years, the estimate is: course marks = mid 80s; average = mid 80s.
  • Students wishing to enroll in this program will initially apply to a general departmental Major (ASMAJ2675) after their first year. After admission, and prior to the start of their third year of study, students will select the focus for their future studies (Biomedical Toxicology or Pharmacology). First and second year courses are the same for all Major programs within the Department (ASMAJ2675/ASMAJ2082/ASMAJ2573).
  • Students cannot combine a Biomedical Toxicology Major program with a Pharmacology Major or Specialist program for their degree.
Completion Requirements:

(8 credits)

First Year: BIO120H1; BIO130H1; ( CHM135H1, CHM136H1)/ CHM151Y1

Second Year: BCH210H1; BIO230H1/​ BIO255H1; PCL201H1; CHM247H1/​ CHM249H1; ( PSL300H1, PSL301H1) (NOTE: PSL201Y1 is not acceptable)

Third Year: PCL302H1; PCL381H1

Third or Fourth Year: 1.0 credit with at least 0.5 credit from PCL courses: JPM300H1/​ JPM400Y1/​ PCL345H1/​ PCL362H1/​ PCL367H1/​ PCL368H1/​ PCL386H1/​ PCL389H1/​ PCL402H1/​ PCL475H1/​ PCL476H1/​ PCL477H1/​ PCL484H1/​ PCL490H1/​ ANA301H1/​ LMP301H1/​ LMP363H1

Fourth Year: PCL482H1, PCL483H1

Notes:

  1. Students are not allowed to enroll concurrently in the Major Program in Pharmacology and the Major Program in Toxicology.
  2. Students are not allowed to enroll concurrently in the Major Program in Pharmacology and a Specialist Program in Toxicology.
  3. Students are not permitted to take PCL472Y1 or PCL474Y1.

Pharmacology Major (Science Program) - ASMAJ2082

Pharmacology is an integrative medical science that builds upon the core foundational disciplines of the basic life sciences. This program is intended for students who want to gain knowledge in Pharmacology in combination with a separate and complementary area of study and is designed for students interested in broad, multidisciplinary training. The Pharmacology Major program is designed to provide students with a broad understanding of the therapeutic properties and clinical uses of externally administered chemical substances in the whole body, as well as the mechanisms of their actions and interactions with molecular, cellular and tissue targets. Students learn about both basic and clinical pharmacology through lectures, tutorials and small group sessions.

This understanding prepares students for a variety of either research-based or non-research-based careers, including positions in the pharmaceutical and biotechnology industries, in government agencies, in research institutes and in universities. Pharmacology (and its application in clinical therapeutics) plays a prominent role in society, and a comprehension of drug mechanisms and uses is fundamental to career success in the fields of medicine, dentistry, pharmacy and nursing. While some students take the Pharmacology Major program in preparation for these professional programs, students are advised to contact the respective Faculties directly for questions related to transfer credits.

Enrolment Requirements:

This is a limited enrolment program. Students must have completed 8.0 credits and meet the requirements listed below to enroll. Students interested in this program should initially apply to the general Major (ASMAJ2675) after their first year of study. Following their second year of study, students in ASMAJ2675 must choose to pursue either the Pharmacology Major (ASMAJ2082) or the Biomedical Toxicology Major (ASMAJ2573).

Students who have completed 4.0 to 7.5 credits cannot apply directly to ASMAJ2082 and must first apply to ASMAJ2675, using the following courses:

Students who have completed at least 8.0 credits and who are already enrolled in ASMAJ2675 may enrol in ASMAJ2082 themselves on ACORN.

Students who have completed at least 8.0 credits but who are not already enrolled in ASMAJ2675 must apply to ASMAJ2082 using the following courses:

Variable Minimum Grade and Variable Minimum Grade Average
A minimum grade and minimum grade average in required courses are needed for entry, and this minimum changes each year depending on available spaces and the number of applicants.

To ensure that students admitted to the program will be successful, applicants with a final grade lower than 65% in each course, or a combined grade average lower than 70% in these required courses will not be considered for admission. Please note that obtaining this minimum final grade and minimum grade average does not guarantee admission to the program. The underlying numeric final mark in each of your courses required for program enrolment will be used by the relevant academic unit to determine your eligibility.

Applications from students lacking numerical grades in one or more of the specified enrolment requirements, or students applying in their second or later years, may be considered on the basis of their entire academic record and the availability of space in the program. In addition to applying through ACORN, students applying in their second year or later are asked to please contact the department directly at undergrad.pharmtox@utoronto.ca, specify which program you would like to be considered for, and provide your student number. Please consult the Arts & Science Program Toolkit for more information on program enrolment.

Notes:

  • While it is difficult to predict what will be competitive course marks and average in a given year, based on previous years, the estimate is: course marks = mid 80s; average = mid 80s.
  • Students wishing to enroll in this program will initially apply to a general departmental Major (ASMAJ2675) after their first year. After admission, and prior to the start of their third year of study, students will select the focus for their future studies (Biomedical Toxicology or Pharmacology). First and second year courses are the same for all Major programs within the Department (ASMAJ2675/ASMAJ2082/ASMAJ2573). Students cannot combine a Pharmacology Major program with a Pharmacology Major or Specialist program for their degree.
  • Students wishing to enroll after their second year who have taken PCL201H1 will be considered on a case by case basis. Successful completion of required pre-requisite courses is required to further enroll in upper level program courses.
Completion Requirements:

(8 credits)

First Year: BIO120H1; BIO130H1; ( CHM135H1, CHM136H1)/ CHM151Y1

Second Year: BCH210H1; BIO230H1/​ BIO255H1; PCL201H1; CHM247H1/​ CHM249H1; ( PSL300H1, PSL301H1) (NOTE: PSL201Y1 is not acceptable)

Third Year: PCL302H1; BCH311H1/​ PSL350H1

Third or Fourth Year: PCL469H1 and 1.0 credit from: JPM300H1/​ JPM400Y1/​ PCL345H1/​ PCL367H1/​ PCL368H1/​ PCL386H1/​ PCL389H1/​ PCL402H1/​ PCL475H1/​ PCL476H1/​ PCL477H1/​ PCL484H1/​ PCL490H1

Fourth Year: PCL470H1

Notes:

  1. Students are not allowed to enroll concurrently in the Major Program in Pharmacology and the Major Program in Toxicology.
  2. Students are not allowed to enroll concurrently in the Major Program in Pharmacology and a Specialist Program in Toxicology.
  3. Students are not permitted to take PCL472Y1 or PCL474Y1.

Pharmacology and Toxicology Courses

PCL102H1 - The Art of Drug Discovery

Hours: 24L

This course introduces students to the processes and strategies for discovering new drugs with a special focus on current and emerging approaches for the rational design of drugs that are both effective and safe.

Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL200H1 - Drugs & the Brain

Hours: 24L

Lectures introduce students to prescribed and illicit drugs that affect the brain. Lectures cover drug pharmacology and explain how drugs alter mood, perception, cognition, and arousal by affecting different aspects of brain function. The societal impact of these prescribed and illicit drugs is also discussed.

Note: This course is not intended for upper-year students who have already completed BCH210H1 or other exclusion courses. Upper-year Life Science students who are excluded and are interested in this content should look into PCL475H1 and/or PCL476H1 as the more appropriate choice.

Exclusion: PSY396H1, PCL302H1, BCH210H1, BCH242Y1, PSYC62H3
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL201H1 - Introduction to Pharmacology and Pharmacokinetic Principles

Hours: 36L/6T

A general introduction to the principles of pharmacology and pharmacokinetics. Topics include chemical (drug) absorption, distribution, biotransformation, elimination; the calculation of dosages and pharmacokinetic parameters, variability in drug response, adverse drug reactions and special interest topics.

Prerequisite: BIO130H1/ BIOA01H3/ BIO152H5
Corequisite: Recommended Co-requisites: BIO230H1/ BIO255H1, PSL300H1/ PSL301H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL218H1 - Cannabis the Drug

Hours: 24L

There is a critical need for a breadth of understanding regarding its mechanism of action, pharmacological effects and its potential benefits and harms (short- and long-term). Students will gain a breadth of understanding in cannabis-related topics including pharmacology and toxicology, its role in mental health and addictions, medical use, drug policy and new drug development that stems from increased access to cannabis constituents. They will learn to differentiate myths and anecdotes from evidence-based knowledge. Going forward it is imperative that students spanning basic sciences through business, arts and engineering have a comprehensive understanding of these topics. PCL218H1 will give students for a variety of academic backgrounds a basic understanding of the health implications of cannabis which have broad implications for both our professional and personal lives.

Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL297H1 - Research Experience in Pharmacology & Toxicology

Hours: 60P

A formal opportunity to gain hands-on experience and develop their skills within a research laboratory setting. Students will have a chance to become familiar and efficient at good lab practices, develop critical thinking and evaluation skills while applying their knowledge and developing trouble shooting skills to practical research questions. Students are required to participate in active research for the equivalent of a minimum of 60 hours of laboratory time. This course is Pass/Fail. Not eligible for CR/NCR option. NOTE: students are required to secure their own supervisor for the course.

Permission of Faculty Supervisor and Department required.

Additional student information resources and enrollment form for the course can be found on the Pharmacology & Toxicology website here: https://pharmtox.utoronto.ca/undergraduate-courses

Prerequisite: Completion of at least 4.0 credits.
Recommended Preparation: Completion of at least first year of Life Sciences program.
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL299Y1 - Research Opportunity Program

Credit course for supervised participation in faculty research project. Details at https://www.artsci.utoronto.ca/current/academics/research-opportunities/research-opportunities-program. Not eligible for CR/NCR option.

Distribution Requirements: Science

JPM300H1 - Research Readiness and Advancing Biomedical Discoveries

Hours: 12L/24T

Explore how scientists leverage their knowledge and skills to advance academic biomedical discoveries from the laboratory to improve patient health through either commercialization or not-for-profit approaches. Students will learn about innovation and develop key research and industry skills including intellectual property, ethics, budget and project management; learn how to critically evaluate scientific evidence and effectively communicate to a wide audience. This hybrid student-centered course will include interactive online modules and in-class group work. Course work will focus on developing skills and knowledge to help you be successful in diverse research courses and future careers. Not eligible for CR/NCR option.

Prerequisite: Completion of 10.0 credits, BCH210H1/ BCH242Y1
Recommended Preparation: PSL300H1, PSL301H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL302H1 - Pharmacodynamic Principles

Hours: 36L

Topics include biological action of drugs on membranes, enzymes, receptors, neural and hormonal systems, transmission and modulation.

Prerequisite: ( PSL300H1, PSL301H1)
Exclusion: PHC300H1, PHC301H1
Recommended Preparation: PCL201H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL345H1 - Experimental Approaches in Drug Discovery

Hours: 24L

Lecturers use their own research to demonstrate how they approach a biological question. The lectures emphasize why one approach is chosen over other possible approaches, and explain the strengths and limitations of techniques. Following the one-hour lecture there is an interactive discussion of the experimental approach covered in the lecture.

Prerequisite: One of PSL300H1/ PSL301H1/ BIO270H1/ BIO271H1, and completion of 10.0 credits. Students who do not meet the prerequisite are encouraged to contact the Department.
Recommended Preparation: BCH210H1, PCL201H1, PCL302H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL362H1 - Introductory Toxicology

Hours: 27L/5T

Toxicological problems encountered in animals and humans; biochemical mechanisms and clinical factors of toxicological significance; models of drug-related diseases.

Prerequisite: BIO130H1/ BIOA01H3/ BIO152H5, PCL201H1 or Permission of the Department
Corequisite: Recommended Co-requisite: PCL302H1, BCH311H1/ CSB349H1
Recommended Preparation: BCH210H1, CHM247H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL367H1 - Drug Development Pipeline I: In vitro

Hours: 8T/40P

This course will provide a learning experience that simulates the process, techniques, analysis and evaluation methods used for early-stage in vitro drug development. Modules will build on the student’s fundamental knowledge and will simulate and illustrate the thought processes and techniques that are used during new drug development in academic research institutes, clinical research organizations and pharmaceutical and biotechnology companies worldwide. Modules include target screening, cytotoxicity assays, transcriptional activation testing and metabolizing enzyme identification experiments. This experience will allow students to leverage their learned knowledge to improve their employability in this area, while honing their critical thinking and analytical skills. (Lab Materials Fee: $25)

Prerequisite: PSL300H1, PSL301H1
Corequisite: PCL302H1
Recommended Preparation: PCL201H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL368H1 - Drug Development Pipeline II: In vivo

Hours: 8T/40P

This course will provide a learning experience that parallels and simulates the process, protocols, methods and evaluation tools used for later-stage in vivo drug development. Modules will build on the student’s fundamental knowledge and simulate the thought processes and techniques used during drug development in research institutes, clinical research organizations and pharmaceutical and biotechnology companies worldwide. Modules will include pharmacokinetic and pharmacodynamic analyses and pharmacogenetic screening approaches in model systems and humans. This experience will allow students to leverage their learned skills and knowledge to improve their comprehension and employability in this area, while honing critical thinking and analytical skills. (Lab Materials Fee: $25)

Prerequisite: PSL300H1, PSL301H1, PCL201H1, PCL302H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL376H1 - Experimental Design and Data Analysis for Pharmacology and Toxicology

Hours: 30L/6T

This course includes lectures focused on experimental design and the analysis of pharmacological and toxicological data. Topics include: principles of experimental design, data analysis and statistical tests appropriate for each type, use of computing statistical packages, analysis of dose-response and time-response curves and analysis of receptor binding assays. Practical applications and problem sets will be taken up in class and in tutorials. Not offered every year.

Prerequisite: PCL201H1
Corequisite: PCL302H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL381H1 - The Molecular and Biochemical Basis of Toxicology

Previous Course Number: PCL481H1

Hours: 24L/12T

The biochemical principles and molecular mechanisms underlying the toxicity of drugs and foreign agents. The sequence of events at the molecular level leading to impairment of cell function and the factors which determine and affect toxicity.

Prerequisite: PCL302H1
Exclusion: PCL481H1
Recommended Preparation: BCH210H1/ BCH242Y1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL386H1 - Pharmacology of Cancer Signaling

Previous Course Number: PCL486H1

Hours: 24L

This course will expand on both classical and cutting edge pharmacological strategies proposed to mitigate the consequences of altered signal transduction in cancer. Students will have the opportunity to develop knowledge on these molecular events and how they can be targeted to improve clinical outcomes. Students will integrate lecture material with assigned readings and assignments.

Prerequisite: BCH210H1/ BCH242Y1, and completion of at least 10.0 credits, or Permission of the Department
Exclusion: PCL486H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL389H1 - Understanding the Role of Pharmacology and Toxicology in Society

Hours: 24L

This service learning course explores issues surrounding the effects that pharmaceuticals and chemicals have in society. Specifically, it integrates pharmacology and toxicology with social, health and political issues as they relate to drug abuse and addiction. Students are required to interact and work with community partners during the semester (approx. 20hrs). Classroom discussions will integrate community experiences with lecture material. Not eligible for CR/NCR option.

Prerequisite: PCL201H1
Corequisite: PCL302H1; ( PSL300H1, PSL301H1)
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL397Y0 - Research Abroad in Pharmacology and Toxicology

Hours: 200P

An independent research project in a pharmacology and/or toxicology laboratory in an approved partner university. This international research experience will be supervised by a faculty member at the partner institution and will allow students to develop critical thinking and evaluation skills while applying their knowledge and trouble shooting skills to practical research questions. Information regarding eligibility, application process and upcoming information session dates can be found on the Department of Pharmacology and Toxicology website here: PCL397Y0 Website. Not eligible for CR/NCR option. Contact undergrad.pharmtox@utoronto.ca for more information.

Prerequisite: PCL201H1 (65%), PSL300H1 (65%), PSL301H1 (65%); permission from the Undergraduate Coordinator
Recommended Preparation: PCL302H1 (65%)
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL397Y1 - Research Abroad in Pharmacology and Toxicology

Hours: 200P

An independent research project in a pharmacology and/or toxicology research laboratory for inbound exchange students coming to the University of Toronto from an approved partner university. This research experience will be supervised by a faculty member and will allow students to develop critical thinking, communication and evaluation skills while applying their knowledge and trouble shooting skills within leading edge research questions. Information regarding eligibility, application process and upcoming information session dates can be found on the Department of Pharmacology and Toxicology website here: PCL397Y1 Website. Not eligible for CR/NCR option. Contact undergrad.pharmtox@utoronto.ca or the Centre for International Experience https://internationalexperience.utoronto.ca/ for more information.

Prerequisite: Completion of at least 8.0 credits, permission from the Department. Background course work in Pharmacology and Physiology strongly recommended.
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)
Course Experience: University-Based Experience

PCL399Y1 - Research Opportunity Program

Credit course for supervised participation in faculty research project. Details at https://www.artsci.utoronto.ca/current/academics/research-opportunities/research-opportunities-program. Not eligible for CR/NCR option.

JPM400Y1 - Biomedical Incubator Capstone Project

Hours: 240P/16S

Discover what it is like to be part of a biomedical innovation team. Develop and engage in biomedical research in a simulated small business/incubator setting under the guidance of a faculty mentor. Bring your proposed JPM300H1 project to life, while acquiring budget management, research, business and communication workplace skills for future careers. Enrolment is application-based. Application requirements and process are presented as part of the JPM300H1 course. Proposals will be reviewed by committee and successful proposals will be matched to a mentor. Not eligible for CR/NCR option.

Application required; contact department (undergrad.pharmtox@utoronto.ca) for more information.


Students will form teams and develop a research proposal based on either:

1. Faculty led concept requiring further development and testing, which would not normally be funded grants and would be tangential to ongoing research in the lab.

2. Student developed innovative idea that requires further development and testing. This should be a project that is not being investigated in a UofT research lab.

Prerequisite: A minimum of 75% in JPM300H1; completion of any of PCL367H1/ PCL368H1/ PSL372H1/ BCH370H1/ BCH377H1.
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL402H1 - Pharmacology and Toxicology in Drug Development

Hours: 24L/12T

This course provides the basic principles of drug development, with a primary focus on the application of fundamental principles of pharmacology and toxicology to the design of preclinical assays and early phase clinical trials. Students in the course will have the opportunity to engage in experiential learning in drug development projects for rare diseases.

Prerequisite: PCL201H1, PCL302H1
Corequisite: PCL470H1/ PCL482H1
Recommended Preparation: PSL300H1, PSL301H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL469H1 - Systems Pharmacology I

Previous Course Number: PCL470Y1

Hours: 31L/4T

A culmination of pharmacological principles discussing concepts of drug properties and their interactions within the body. The mechanism of action, pharmacological properties including clinical use and adverse effects of drugs acting on the autonomic nervous systems, cardiovascular, renal, respiratory, gastrointestinal and endocrine systems will be examined. Critical evaluation of primary literature and examination of clinical problem-based case studies will be integrated with lecture material through small group sessions.

Prerequisite: PCL201H1, PCL302H1, ( PSL300H1, PSL301H1)
Exclusion: PCL470Y1
Recommended Preparation: BCH210H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL470H1 - Systems Pharmacology II

Previous Course Number: PCL470Y1

Hours: 31L/4T

A culmination of pharmacological principles discussing concepts of drug properties and their interactions within the body. The mechanism of action, pharmacological properties including clinical use and adverse effects of drugs acting on the central nervous systems and immunological system; antimicrobial and cancer chemotherapeutic agents as well as the potential therapeutic use of endogenous/herbal compounds will be examined. Critical evaluation of primary literature and examination of clinical problem-based case studies will be integrated with lecture material through small group sessions.

Prerequisite: PCL201H1, PCL302H1, ( PSL300H1, PSL301H1), and 14.0 credits. Students who do not meet the prerequisite are encouraged to contact the Department.
Exclusion: PCL470Y1
Recommended Preparation: BCH210H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL472Y1 - Project in Pharmacology

This course affords students an opportunity for hands-on research experience in a laboratory or applied pharmacology setting. Students will work under the supervision of a faculty member and will submit a final written report and oral presentation. Enrollment is limited to students in ASSPE2340/ASSPE2082 programs and requires permission from the Department of Pharmacology and Toxicology. It is the student’s responsibility to secure a placement with an approved supervisor before the course begins (a list of potential supervisors will be provided by the Department of Pharmacology and Toxicology). Students will be registered in the course once their ballot form (obtained from the Department) is signed by an approved supervisor and approved by the Department of Pharmacology and Toxicology. Eligible students will be contacted by the Department during the Winter term, occurring prior to their final year of study (i.e. 3rd year of study for most), with details and instructions to apply. Students are expected to spend approximately 200 hours towards this project but this will be project/supervisor dependent. Not eligible for CR/NCR option.

Prerequisite: PCL201H1, PCL302H1, PCL367H1/ PCL368H1, STA288H1/ STA220H1/ PSY201H1
Exclusion: PCL474Y1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL474Y1 - Project in Toxicology

This course affords students an opportunity for hands-on research experience in a laboratory or applied toxicology setting. Students will work under the supervision of a staff member and will submit a final written report and oral presentation. Enrollment is limited to students in ASSPE2340/ASSPE2573/ASSPE0605 programs and requires permission from the Department of Pharmacology and Toxicology. It is the student’s responsibility to secure a placement with an approved supervisor before the course begins (a list of potential supervisors will be provided by the Department of Pharmacology and Toxicology). Students will be registered in the course once their ballot form (obtained from the Department) is signed by an approved supervisor and approved by the Department of Pharmacology and Toxicology. Eligible students will be contacted by the Department during the Winter term, occurring prior to their final year of study (i.e. 3rd year of study for most), with details and instructions to apply. Students are expected to spend approximately 200 hours towards this project but this will be project/supervisor dependent. Not eligible for CR/NCR option.

Prerequisite: PCL201H1, PCL302H1, PCL367H1/ PCL368H1, STA288H1/ STA220H1/ PSY201H1
Exclusion: PCL472Y1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL475H1 - Neuropsychopharmacology 1

Previous Course Number: PCL475Y1

Hours: 36L/12T

This course examines drugs whose primary effect is to alter the operation of the brain and mind (cognition, emotion). Key topics include the neurophysiology of: Pain, Anesthesia, Psychoactive Drug Effects, Addiction, Epilepsy, and Psychomotor Control. The brain mechanisms that mediate each of these processes or syndromes will be described along with pharmacological strategies to probe and regulate them. Chronic drug effects will be discussed to illustrate how the brain changes with ongoing exposure to different drugs. Evaluation is based on 3 non-cumulative tests (2 mid-terms, 1 final exam) and a written assignment.

Prerequisite: Completion of 9.0 credits
Exclusion: PCL475Y1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL476H1 - Neuropsychopharmacology 2

Previous Course Number: PCL475Y1

Hours: 36L/12T

Students will explore the major CNS neurological syndromes which may include anxiety, schizophrenia and depression/mania and their relate neurological abnormalities. Lectures will discuss major classes of drugs used to mitigate and treat these disorders, their mechanisms of action, clinical use and unwanted effects. Not offered every year.

Prerequisite: Completion of 9.0 credits, and PCL475H1. Students who do not meet the prerequisite are encouraged to contact the Department.
Exclusion: PCL475Y1, PSY396H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL477H1 - The DNA Damage Response in Pharmacology and Toxicology

Hours: 24L

Many anticancer drugs and environmental agents exert their cytotoxic effects through DNA damage. This course explores specific pharmacological and toxicological agents that damage DNA and discusses how mammalian cells respond to this DNA damage.

Prerequisite: BCH210H1/ BCH242Y1, completion of 9.0 credits
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL482H1 - Biomedical Toxicology

Previous Course Number: PCL473Y1

Hours: 24L

This course explores several contemporary topics in biomedical toxicology with emphasis on how chemicals affect human health. Lectures cover principles of toxicology, the mechanisms of toxicity of a wide variety of toxic agents and the associated toxicities, methodologies used to examine chemical toxicities, risk assessment, and the applications of toxicology.

Prerequisite: Completion of 14.0 credits including PCL201H1, PCL302H1, and one of PCL362H1/ PCL381H1. Students who do not meet the prerequisite are encouraged to contact the Department.
Exclusion: PCL473Y1
Recommended Preparation: BCH210H1 and BCH311H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL483H1 - Interdisciplinary Toxicology

Previous Course Number: PCL473Y1

Hours: 24L

This course explores several contemporary topics in biomedical and environmental toxicology with emphasis on how chemicals affect human health. Lectures cover principles of toxicology, the mechanisms of toxicity of a wide variety of toxic agents and the associated toxicities, methodologies used to examine chemical toxicities, risk assessment, and the applications of toxicology.

Prerequisite: ( PCL201H1, PCL302H1, and one of PCL362H1/ PCL381H1) or Permission of the Course Coordinator
Exclusion: PCL473Y1
Recommended Preparation: BCH210H1 + BCH311H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL484H1 - Seminars in Pharmacokinetics and Toxicokinetics

Hours: 24S

Each week a scientist affiliated with the Department of Pharmacology and Toxicology will discuss the application of pharmacokinetic and/or toxicokinetic principles to their research. This area of study plays an important role in clinical medicine and drug development

Prerequisite: PCL201H1
Recommended Preparation: PCL302H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PCL490H1 - Advanced Topics in Pharmacology and Toxicology

Hours: 12L/12S

An opportunity to expand on innovative and unique topics in Pharmacology and Toxicology that are not already extensively addressed. The course will reveal the dynamic nature of the field and the diverse interests of our faculty. Students will be introduced to leading edge topics and research within the discipline of Pharmacology and Toxicology.

Prerequisite: PCL302H1, one of STA288H1/ STA220H1/ PSY201H1, completion of 14.0 credits. Students who do not meet the prerequisite are encouraged to contact the Department.
Recommended Preparation: PCL469H1/ PCL470H1/ PCL482H1/ PCL483H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

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