Current approaches to using the computer for analyzing and modeling biology as integrated molecular systems. Lectures plus hands-on practical exercises. The course extends and complements an introductory Bioinformatics course.

An opportunity for advanced specialized individual research in bioinformatics and computational biology by arrangement with a supervisor. Approval of the application by the BCB coordinator is required.  BCB330Y1 is a recommended preparation for this course however students should not normally conduct their project in the same laboratory or continue their previous project. Not eligible for CR/NCR option.

This introductory course in biochemistry will cover the fundamentals of proteins, enzymes, biological membranes and the metabolism of carbohydrates and lipids for energy production. This course is intended for students who are NOT taking BCH242Y1 as part of their program.

This introductory course in biochemistry will serve as the foundation for upper-level BCH courses taken by students specializing in biochemistry and related specialist programs. The major topics include protein structure, enzyme mechanisms and function, gene expression, lipid and membrane structure and function, and the metabolism of carbohydrates, lipids and amino acids for energy production. Laboratory techniques will also be introduced to understand the role of biochemistry for research. Please note that there are five laboratories accompanying this course. (Lab fees:$10)

Credit course for supervised participation in faculty research project. Details at https://www.artsci.utoronto.ca/current/academics/research-opportunities/research-opportunities-program. Not eligible for CR/NCR option.

Nucleic acids and flow of information in biological systems. Information storage and transmission by nucleic acids, as well as new molecular technologies will be discussed. Registration in one of the tutorial sessions is mandatory. Note: Students that have a SDF in BCH210H1 are not permitted to enrol in BCH311H1 until a final passing grade (50%) appears on the transcript. BCH2** WITH COURSE EXCLUSION TO BCH210H1 meets the prerequisite requirement for BCH311H1.

Proteins are the main functional units in the cell. In this course, a detailed overview of protein structure and function will be given with strong emphasis on the basic principles in the field. Students will be introduced to folded and intrinsically disordered proteins. Biophysical methods to study protein stability and folding will be discussed, as well as experimental approaches to determine protein structure and function. Students will be introduced to catalysis, kinetics, and the mechanisms that regulate enzyme activity. Finally, proteomic methods to studying protein networks in cells will be presented. The course will offer a solid basis in protein biochemistry. It is recommended for those interested in pursuing graduate studies or professional degrees in health or medicine.

This course is designed to provide hands-on experience at an introductory level, employing a variety of biochemical techniques commonly used in research and clinical diagnostic laboratories. This course is intended for students who are not proceeding further in biochemistry. It is highly recommended that students take this course in their third year as space is limited and priority will go to third-year students. This course will be offered in the FALL & WINTER terms. Attendance in the first week of class is mandatory in order to receive safety information and laboratory protocols. (Enrolment limited.) (Lab fees: $40)

This course provides opportunities to pursue an original individual research project in a particular area of biochemistry, under the direct supervision of a Biochemistry Department faculty member. Students are responsible for arranging for supervision by a Biochemistry Department faculty member. To apply for enrolment, students are required to complete the application form by contacting the Course Coordinator by the end of April. Not eligible for CR/NCR option.

This course provides an opportunity for individual research with a specific topic of study. Students are mentored and supervised by research scientists and faculty associated with the University of Toronto. It provides students an opportunity to enhance and apply their knowledge and understanding learned in other courses. Direct supervision must be provided by a faculty member within the Department of Biochemistry. Not eligible for the CR/NCR option.

This course provides opportunities to pursue an original individual research project in a particular area of biochemistry, under the direct supervision of a Biochemistry Department faculty member. Students are responsible for arranging for supervision by a Biochemistry Department faculty member. To apply for enrolment, students are required to complete the application form by contacting the Course Coordinator before the end of August. Not eligible for CR/NCR option.

This course provides an opportunity for individual research with a specific topic of study. Students are mentored and supervised by research scientists and faculty associated with the University of Toronto. It provides students an opportunity to enhance and apply their knowledge and understanding learned in other courses. Direct supervision must be provided by a faculty member within the Department of Biochemistry. Not eligible for the CR/NCR option.

An introduction to fundamental laboratory techniques in modern biochemistry. Experiments illustrate and develop the concepts described in lecture courses and serve as a foundation for more advanced training in biochemistry laboratory courses. Enrollment in this course is generally restricted to students enrolled in the Biochemistry, Immunology, and Molecular Genetics & Microbiology (Genetics Stream) Specialist programs. (Lab fees: $25)

This course builds upon the fundamental laboratory techniques acquired in BCH377H1. Students gain hands-on experience in experimental design and data analysis, exploring numerous modern and classic biochemistry and molecular biology experimental techniques used in research laboratories. Enrolment in this course is generally restricted to students enrolled in the Biochemistry Specialist program.

Credit course for supervised participation in faculty research project. Details at https://www.artsci.utoronto.ca/current/academics/research-opportunities/research-opportunities-program. Not eligible for CR/NCR option.

Structural features of membrane proteins, their biogenesis and methods of analysis. Function of membrane proteins as transporters, channels, pumps and receptors. Molecular aspects of disease processes linked to membrane proteins.

Theory of modern biophysical techniques as applied to the study of the structure and function of macromolecules; emphasis on X-ray crystallography, electron cryomicroscopy, NMR spectroscopy, and other spectroscopic methods.

This course is focused on the molecular aspects of signal transduction, covering how cells receive and then transmit signals via intracellular proteins such as kinases and phosphatase and how this ultimately regulates cell function. Specific topics covered include regulation and signalling by extracellular ligands including morphogens, growth factors and/or insulin, how signalling pathway crosstalk modulates cell function and low and high throughput methodological approaches used to elucidate signalling mechanisms.

There is a growing appreciation that microbes do not operate in isolation but form parts of larger populations and communities (microbiomes) with unique considerations for human health. Combining lectures, small group discussions, and a computer lab component, this course will cover how genomics can be applied to analyze microbial communities and the transformative discoveries that continue to result.

Protein homeostasis is dependent on the coordinated synthesis, folding, localization and degradation of the thousands of proteins in a living cell. This course deals with selected aspects of the process with emphasis on: i) protein folding and the role of chaperones, ii) protein degradation via the ubiquitin proteasome system, iii) protein folding and quality control in the ER and iv) ER-associated degradation and the unfolded protein response. The course will serve as a foundation for those with an interest in how cellular protein levels and conformations are maintained.

This course examines the molecular details of the secretory and endocytic pathways in the cell. Some of the specific topics covered will include protein translocation into the ER, chaperones and protein folding in the ER, retrotranslocation and protein degradation, the Unfolded Protein Response (UPR), vesicle biogenesis and ER-Golgi transport, regulated secretion, basic concepts in endocytosis and protein sorting in polarized cells. Emphasis is placed on current experimental approaches. A good understanding of basic biochemical methods is an asset.

Advanced principles and concepts of cell biology are covered, including the structure, life cycle, and dynamic behavior of cell organelles. The cellular processes regulated by organelles, including the life and death of the cell and cellular communication, are highlighted. The course will also cover techniques and technologies that have advanced studies of the cell.

This course covers the principles and concepts related to molecular cell biology of the cell surface in multicellular organisms. Topics include: biophysical properties of cells, membranes, and extracellular matrix, dynamic remodelling of the cytoskeleton; cell-cell and cell-matrix interactions; maintenance of planar and apical-basal cell polarity; cytokinesis, viral uptake by macropinocytosis and engulfment by phagocytosis. In addition to lectures, groups of students will interpret a recent scientific paper related to the course material to be formally presented during regular class hours.

This course examines the structure and function of the cell nucleus and the genome through the lens of biochemistry, molecular biology, cell biology and evolution. A focus is placed on the major scientific developments that shaped our current understanding. Topics that will be covered are eukaryogenesis, junk DNA, the structure of DNA and chromatin, the transfer of information between genotype and phenotype, the filtering of information found in the genome into biologically relevant molecules such as mRNA, the processing and export of these products from the nucleus into the cytoplasm, and the translation of mRNA into protein. We will also investigate how various organelles, such as the endoplasmic reticulum and mitochondria, played a role in the evolution of the nucleus. Finally we will investigate how biological information is partitioned during mitosis.

This course will apply core biochemical principles to explain the pathogenesis of emerging diseases at the molecular level and describe advanced biochemical technologies used to understand and treat these illnesses. Students will be exposed to how biochemical principles influence medical diagnoses, therapy and the development of new drugs.

This course will cover the action of the biochemical targets of the existing antibiotics (nucleotide-, RNA-, DNA-, protein- and cell wall synthesis, the manner in which these pathways are inhibited in antimicrobial therapy and the biochemical basis of antibiotic resistance. The biochemistry and origin of naturally occurring and synthetic antibiotics will be introduced. (Enrolment limited.)

This course provides an opportunity for individual research with a specific topic of study. Students are mentored and supervised by research scientists and faculty associated with the University of Toronto. It provides students an opportunity to enhance and apply their knowledge and understanding learned in other courses. Direct supervision must be provided by a faculty member within the Department of Biochemistry. Not eligible for the CR/NCR option.

This course provides an opportunity for individual research with a specific topic of study. Students are mentored and supervised by research scientists and faculty associated with the University of Toronto. It provides students an opportunity to enhance and apply their knowledge and understanding learned in other courses. Direct supervision must be provided by a faculty member within the Department of Biochemistry. Not eligible for the CR/NCR option.

This course provides opportunities to pursue an original individual research project in a particular area of biochemistry, under the direct supervision of a Biochemistry Department faculty member. Students are responsible for arranging for supervision by a Biochemistry Department faculty member. To apply for enrolment, students are required to complete the application form by contacting the Course Coordinator by the end of April. Not eligible for CR/NCR option.

This course provides opportunities to pursue an original individual research project in a particular area of biochemistry, under the direct supervision of a Biochemistry Department faculty member. Students are responsible for arranging for supervision by a Biochemistry Department faculty member. To apply for enrolment, students are required to complete the application form by contacting the Course Coordinator before the end of August. Not eligible for CR/NCR option.