Chemistry


Faculty List

University Professors Emeriti
J.B. Jones, BSc, PhD, D Phil, FRSC, FCIC 
J.C. Polanyi, MSc, PhD, D SC, FRS, FRSC, FRSEd

Professors Emeriti
D.J. Donaldson, BSc, PhD (University of Toronto Scarborough)
M. Georges, PhD (University of Toronto Mississauga)
R.E. Kapral, BSc, PhD, FRSC
U.J. Krull, BSc, PhD, FCIC (University of Toronto Mississauga)
P.M. Macdonald, MSc, PhD (University of Toronto Mississauga)
R.A. McClelland, BSc, PhD, FRSC (University of Toronto Scarborough) 
S. McLean, BSc, PhD, FCIC 
M. Menzinger, Dip Eng, MSc, PhD (SM) 
W.F. Reynolds, MSc, PhD 
E.A. Robinson, BSc, PhD, D Sc (University of Toronto Mississauga) 
I.W.J. Still, BSc, PhD, D Sc (University of Toronto Mississauga) 
T.T. Tidwell, BSc, AM, PhD, FRSC (University of Toronto Scarborough) 
J.P. Valleau, MA, PhD (I) 
S.G. Whittington, MA, PhD (T) 

Professor Emerita, Teaching Stream
J. C. Poë, ARCS, MSc, DIC, FCIC (University of Toronto Mississauga) 

Associate Professors Emeriti
S.J. Fraser, BA, PhD (University of Toronto Scarborough)

Associate Professors Emeriti, Teaching Stream
C.S. Browning, MSc, PhD (SM) effective July 1, 2024
C.M. Kutas, BSc, MA, PhD

Senior Lecturers Emeriti
S. Skonieczny, D Sc, PhD 
H. O. Ohorodnyk, MSc 

Professor and Chair of the Department
M. Lautens, BSc, PhD, OC, FCIC, FRSC (T)

Associate Professor and Associate Chair (Graduate)
M.S. Taylor, BSc, PhD

Professor, Teaching Stream and Associate Chair (Undergraduate)
A.P. Dicks, BSc, PhD (SM)

University Professors
P.W. Brumer, BSc, PhD, FRSC 
E. Kumacheva, MSc, PhD, FRSC 
M. Lautens, BSc, PhD, OC, FCIC, FRSC (T) 
R.J.D. Miller, BS, PhD, FRSC, FCIC 
G.A. Ozin, BSc, D Phil, FRSC, FCIC 
J.C. Polanyi, MSc, PhD, D Sc, FRS, FRSC, FRSEd 
D.W. Stephan, BSc, PhD, FCIC, FRSC, FRSC(UK), FRS
M.A. Winnik, BA, PhD, FRSC, FCIC 

Professors
J.P. Abbatt, BSc, PhD, FRSC
A. Aspuru-Guzik, BSc, PhD
J. Chin, MSc, PhD 
M.C. Goh, BS, PhD (U) 
P. Gunning, BSc, PhD (University of Toronto Mississauga) 
A. Hargrove, BSc, PhD (University of Toronto Mississauga) effective July 1, 2024
A.F. Izmaylov, MSc, PhD (University of Toronto Scarborough)
R.H. Kluger, AM, PhD, FCIC, FRSC 
H.B. Kraatz, PhD (University of Toronto Scarborough) 
S.A. Mabury, BS, PhD (U), FRSC 
R.H. Morris, BSc, PhD, FRSC, FCIC 
J.G. Murphy, BSc, PhD
M. Nitz, BSc, PhD 
R.S. Prosser, MSc, PhD (University of Toronto Mississauga)
J.M. Schofield, BA, PhD 
D.S. Seferos, BSc, PhD
D. Segal, BSc, PhD
A.J. Simpson, BSc, PhD (University of Toronto Scarborough) 
M.J. Simpson, BSc, PhD (University of Toronto Scarborough) 
M.S. Taylor, BSc, PhD 
M. Thompson, BSc, PhD, D Sc, FRSC, FCIC 
A. von Lilienfeld, BSc, PhD
G. Walker, BA, PhD 
F. Wania, BSc, PhD (University of Toronto Scarborough) 
A. Wheeler, BSc, PhD 
G.A. Woolley, BSc, PhD 
A. Yudin, BS, PhD 

Associate Professors
A. Beharry, PhD (University of Toronto Mississauga)
A. Dhirani, MSc, PhD 
U. Fekl, MSc, PhD (University of Toronto Mississauga) 
R.A. Jockusch, BA, PhD
V. Kanelis, BSc, PhD (University of Toronto Mississauga) 
K. Kerman, MSc, PhD (University of Toronto Scarborough) 
D.R. McMillen, MA Sc, PhD (University of Toronto Mississauga) 
H. Peng, BSc, PhD
S. Rousseaux, BSc, PhD
J.A. Shin, AB, PhD (University of Toronto Mississauga) 
D. Song, BSc, PhD 
M. Wilson, MSc, PhD
X. Zhang, MSc, PhD (University of Toronto Scarborough) 

Assistant Professors
H. Cui, BSc, PhD
X. Li, BSc, PhD
S. Rauscher, BSc, PhD (University of Toronto Mississauga)
R. Sullan, BSc, PhD (University of Toronto Scarborough)
H. Tran, PhD
O. Voznyy, PhD (University of Toronto Scarborough)

Associate Professors, Teaching Stream
C.S. Browning, MSc, PhD (SM) 
S. Dalili, MSc, PhD (University of Toronto Scarborough) 
J. D'eon, BSc, PhD
A. Hadzovic, PhD (University of Toronto Scarborough) 
L. Mikhaylichenko, MSc, PhD (University of Toronto Scarborough)
B. Morra, BSc, PhD
P.A.E. Piunno, MSc, PhD (University of Toronto Mississauga) 
K. Quinlan, BSc, PhD 
E. Sauer, B Sc, PhD (University of Toronto Scarborough) 
D.C. Stone, BSc, PhD 

Assistant Professors, Teaching Stream
J. De Backere, BSc, PhD
K. Kim, BSc, PhD (University of Toronto Scarborough)
K. Luska, BSc, MSc, PhD
J. Strautmanis, PhD (University of Toronto Mississauga) 

Introduction

Chemistry is a rewarding intellectual pursuit and a dominant force in shaping our civilization. Chemistry places a strong emphasis on an understanding of the structures and properties of individual atoms and molecules, and on using this understanding to interpret and predict the behaviour of matter. Many of the concepts of physics, and the methods of mathematics, are basic to chemistry. Chemistry is of fundamental importance to many other subjects including astrophysics, biological sciences, environmental science, geology, materials science, and medical sciences. These and other aspects of the subject are reflected in the undergraduate courses and programs offered by the Department.

The Department has made extensive changes to its course and program offerings in the last few years. These changes included a revision of first-year course delivery, modifications to later-year courses, and the refreshment of all six specialist programs in Chemistry, Biological Chemistry, Materials Science, Pharmaceutical Chemistry, Synthetic & Catalytic Chemistry, and Chemical Physics. In addition, a brand new Environmental Chemistry major has been launched. Students enrolled in any specialist or major program can select a Focus in Green Chemistry or a Focus in Practical Chemical Analysis as part of their undergraduate experience to highlight their acquired knowledge and skills to potential employers.

Students enrolled in any of the six specialist programs are eligible to participate in the Arts & Science Internship Program stream.

Students can choose between two first-year options according to their intended area of study.

1. CHM151Y1 is the course that is strongly recommended for students who plan to enrol in one of the specialist programs involving chemistry (including Biological Chemistry and Pharmaceutical Chemistry), or who plan to include a substantial amount of chemistry in their degree (such as those following a Chemistry major program. CHM151Y1 features a unique Course Community that significantly supports and enhances the student learning experience through informal sessions facilitated by upper-year undergraduate mentors.

2. The combination of CHM135H1 and CHM136H1 is recommended for students who intend to take programs in the Life or Health Sciences that do not require a large amount of chemistry.

The outlines of these first-year courses, together with those for later-year offerings, are shown in this Calendar. More detailed information is available from the Department and is posted at https://www.chemistry.utoronto.ca/undergraduate/current-students/undergraduate-courses.

Incoming first-year students may find more information about the first-year chemistry courses at https://www.chemistry.utoronto.ca/current-students/first-year-students. Some examples of common concepts from high school chemistry studies that you should be familiar with are listed at https://www.chemistry.utoronto.ca/prospective-students/self-assessment-test

Students who are following programs that contain a substantial number of chemistry courses are strongly advised to take courses in the proper year (i.e., 200-level in the second year, etc.). Following the correct sequence will enhance the level and balance of preparation for all later year courses, and timetable conflicts will be avoided. Students whose current programs may be affected by the introduction of new or revised chemistry courses are advised to consult the Department at the earliest possible opportunity.

Students requiring more information about Chemistry programs and courses are invited to visit the Undergraduate Office, Lash Miller Chemical Laboratories, Room 151, or to initiate contact via email (chem.undergrad@utoronto.ca).

Lab Materials Fee

Some courses in this department have a mandatory Lab Materials Fee to cover non-reusable materials. The fee for each such course is given below in the course description and will be included on the student’s invoice on ACORN.

Regarding Materials Science Courses

Notes

  1. The MSE courses listed in the programs below are administered by the Faculty of Applied Science and Engineering, and are subject to the rules and regulations of that Faculty, including those for term dates, examination periods and deferral practices.
  2. The CHM courses listed for the Materials Science program are described in this section of the Calendar.
  3. Enrollment in MSE courses is done through your own College Registrar. It is not necessary to petition as the courses listed below have been pre-approved for this Specialist Program.
  4. Deferment of Final Exams is NOT generally granted in the Faculty of Applied Science and Engineering.

Chemistry Programs

Biological Chemistry Specialist (Science Program) - ASSPE1995

Consult Professor G. A. Woolley, Department of Chemistry.

Biological Chemistry examines Nature at the molecular level by using a combination of synthetic, inorganic, analytical and physical chemistry as well as the tools of molecular biology and biochemistry. This program provides the setting to understand the chemical reactions and interactions that occur in biological processes, as well as how chemical strategies can be used to control these systems. This program includes sufficient flexibility to allow focus in areas such as bioinorganic, bioorganic, biophysical or medicinal chemistry. Students graduating from this program will be prepared for career paths in the biotechnology, biomedical and pharmaceutical sectors, as well as for research and teaching in related areas of chemistry and biology. This program is accredited by the Canadian Society for Chemistry.

Enrolment Requirements:

This is a limited enrolment program. Students must have completed 4.0 credits and meet the requirements listed below to enrol.

Completed courses (with minimum grades)
The following courses with the stated minimum grades are required:

• ( CHM135H1, CHM136H1) (63% in each)/ CHM151Y1 (63%)

Students in this program have the option to request enrolment in the Arts & Science Internship Program (ASIP) stream. Students can apply for the ASIP stream after Year 1 (Year 2 entry) or after Year 2 (Year 3 entry, starting Fall 2024). Full details about ASIP, including student eligibility, selection and enrolment, are available in the ASIP section of the Arts & Science Academic Calendar. Please note that the majority of students enter ASIP in Fall term of Year 2. Space is more limited for Year 3 entry. Students applying for Year 3 entry must have been admitted to the Biological Chemistry Specialist in the Summer after Year 2.

Completion Requirements:

(14.0 credits, including 3.0 credits from 400-level courses)

First Year: BIO120H1, BIO130H1; CHM151Y1 (strongly recommended)/ ( CHM135H1, CHM136H1); ( MAT135H1, MAT136H1)/ MAT137Y1/​ MAT157Y1

First or Second Year: ( PHY131H1, PHY132H1)/ ( PHY151H1, PHY152H1)

Second and Higher Years:

  1. BCH210H1; BIO230H1/​ BIO255H1; CHM217H1, CHM220H1/​ CHM222H1 ( CHM220H1 recommended), ( CHM236H1, CHM237H1)/ CHM238Y1, CHM249H1
  2. CHM310H1, CHM347H1, CHM348H1, CHM379H1
  3. At least 1.0 credit from the following: CHM317H1, CHM327H1, CHM338H1, CHM343H1, CHM395Y1/​ CHM499Y1/​ PHC489Y1, CHM410H1
  4. CHM437H1, CHM447H1, CHM479H1
  5. Additional 300/400-level BCH or CHM courses to a total of 14.0 credits. CSB450H1 is also acceptable.

Students in this program have the option to complete the Arts & Science Internship Program (ASIP) stream.

Chemical Physics Specialist (Science Program) - ASSPE0600

Consult Professor J. Schofield, Department of Chemistry.

Chemical Physics aims to explain structure and dynamics of molecular and bulk systems in terms of atomic and molecular interactions. Sub-disciplines and specialized topics include reaction dynamics, spectroscopy, optical control of molecular processes, nanoscale science, surface chemistry, theoretical and experimental studies of soft systems (polymers, liquids, biological systems), quantum control and quantum information sciences. The Chemical Physics program will provide students with a solid grounding in physical chemistry, and will prepare students for careers in experimental and theoretical physical sciences, in academia or in research development for companies.

Enrolment Requirements:

This is a limited enrolment program. Students must have completed 4.0 credits and meet the requirements listed below to enrol.

Completed courses (with minimum grades)
The following courses with the stated minimum grades are required:

• ( CHM135H1, CHM136H1) (63% in each)/ CHM151Y1 (63%)

Students in this program have the option to request enrolment in the Arts & Science Internship Program (ASIP) stream. Students can apply for the ASIP stream after Year 1 (Year 2 entry) or after Year 2 (Year 3 entry, starting Fall 2024). Full details about ASIP, including student eligibility, selection and enrolment, are available in the ASIP section of the Arts & Science Academic Calendar. Please note that the majority of students enter ASIP in Fall term of Year 2. Space is more limited for Year 3 entry. Students applying for Year 3 entry must have been admitted to the Chemical Physics Specialist in the Summer after Year 2.

Completion Requirements:

(14.0 credits, including 1.5 credits from 400-level courses)

First Year:

  1. ( CHM151Y1 strongly recommended)/ ( CHM135H1, CHM136H1)
  2. ( MAT135H1, MAT136H1)/ MAT137Y1/​ MAT157Y1
  3. ( PHY131H1, PHY132H1)/ ( PHY151H1, PHY152H1)

Higher Years:

  1. APM346H1, CHM222H1, CHM223H1, CHM326H1/​ PHY356H1, CHM327H1, CHM328H1, MAT223H1/​ MAT240H1, MAT235Y1/​ MAT237Y1, MAT244H1, MAT334H1, PHY250H1, PHY254H1, PHY354H1, PHY350H1, CHM423H1/​ PHY456H1
  2. 2.0 credits from: CHM210H1, CHM217H1, ( CHM236H1, CHM237H1)/ CHM238Y1, ( CHM249H1 strongly recommended)/ CHM247H1, CHM310H1, CHM317H1, CHM338H1, CHM348H1, CHM415H1
  3. Additional 400-level CHM/PHY 0.5 credit courses to a total of 14.0 credits. (Note: CHM395Y1 can be used toward this requirement).

Students in this program have the option to complete the Arts & Science Internship Program (ASIP) stream.

Chemistry Specialist (Science Program) - ASSPE1376

Consult Professor A. Dicks, Department of Chemistry.

The Chemistry Specialist Program provides broad coverage of the core areas of chemistry together with appropriate courses in mathematics and physics during the first three years and allows students to follow a particular area of interest or a more general program in the fourth year. The program is suitable for professional work in any area of chemistry and for entry into graduate school to continue work in any of the sub-fields of chemistry, provided that appropriate options are chosen in the fourth year. This program is accredited by the Canadian Society for Chemistry.

Enrolment Requirements:

This is a limited enrolment program. Students must have completed 4.0 credits and meet the requirements listed below to enrol.

Completed courses (with minimum grades)
The following courses with the stated minimum grades are required:

• ( CHM135H1, CHM136H1) (63% in each)/ CHM151Y1 (63%)

Students in this program have the option to request enrolment in the Arts & Science Internship Program (ASIP) stream. Students can apply for the ASIP stream after Year 1 (Year 2 entry) or after Year 2 (Year 3 entry, starting Fall 2024). Full details about ASIP, including student eligibility, selection and enrolment, are available in the ASIP section of the Arts & Science Academic Calendar. Please note that the majority of students enter ASIP in Fall term of Year 2. Space is more limited for Year 3 entry. Students applying for Year 3 entry must have been admitted to the Chemistry Specialist in the Summer after Year 2.

Completion Requirements:

(14.0 credits, including at least 3.0 credits from 400-level courses)

First Year:

  1. ( CHM151Y1 strongly recommended)/ ( CHM135H1, CHM136H1)
  2. ( MAT135H1, MAT136H1)/ MAT137Y1/​ MAT157Y1
  3. ( PHY131H1, PHY132H1)/ ( PHY151H1, PHY152H1)

Second Year:

  1. CHM217H1, CHM220H1/​ CHM222H1, CHM223H1, ( CHM236H1, CHM237H1)/ CHM238Y1, CHM249H1
  2. MAT235Y1/​ MAT237Y1

Third and Fourth Years:

  1. BCH210H1, CHM326H1/​ CHM328H1, CHM327H1
  2. Additional credits from 300/400-level CHM/ MAT/ another science, including at least three of CHM317H1, CHM338H1, CHM343H1, CHM379H1, CHM395Y1/​ CHM499Y1/​ PHC489Y1, CHM410H1. Minimum 3.0 CHM credits at the 400-level to a total of 14.0 credits.

Students in this program have the option to complete the Arts & Science Internship Program (ASIP) stream.

Materials Science Specialist (Science Program) - ASSPE2424

Consult Professor Andrew Dicks, Department of Chemistry.

This program draws both on the basic sciences of chemistry and physics, and on the more applied areas such as metallurgy or ceramics. Courses dealing with these latter fields are offered through the Department of Materials Science in the Faculty of Applied Science and Engineering. This is an appropriate program for students with career interests in solid-state, polymer, or composite materials industries, or for graduate work in either chemistry or materials science, with an appropriate choice of options. Students may follow the Materials Chemistry path by taking the research course CHM499Y1 or the Materials Science and Engineering path by taking the research courses MSE492H1 and MSE493H1. This program is accredited by the Canadian Society for Chemistry.

Enrolment Requirements:

This is a limited enrolment program. Students must have completed 4.0 credits and meet the requirements listed below to enrol.

Completed courses (with minimum grades)
The following courses with the stated minimum grades are required:

• ( CHM135H1, CHM136H1) (63% in each)/ CHM151Y1 (63%)

Students in this program have the option to request enrolment in the Arts & Science Internship Program (ASIP) stream. Students can apply for the ASIP stream after Year 1 (Year 2 entry) or after Year 2 (Year 3 entry, starting Fall 2024). Full details about ASIP, including student eligibility, selection and enrolment, are available in the ASIP section of the Arts & Science Academic Calendar. Please note that the majority of students enter ASIP in Fall term of Year 2. Space is more limited for Year 3 entry. Students applying for Year 3 entry must have been admitted to the Materials Science Specialist in the Summer after Year 2.

Completion Requirements:

(14.0 credits, including 1.0 credit from 400-level courses)

First Year:

  1. BIO120H1
  2. CHM151Y1 (strongly recommended)/ ( CHM135H1, CHM136H1)
  3. ( MAT135H1, MAT136H1)/ MAT137Y1/​ MAT157Y1
  4. MSE120H1

First or Second Year:

  1. BIO130H1/​ BIO220H1
  2. ( PHY131H1, PHY132H1)/ ( PHY151H1, PHY152H1)

Second Year and Higher Years:

  1. CHM220H1/​ CHM222H1/​ MSE202H1*, CHM223H1, ( CHM236H1, CHM237H1)/ CHM238Y1, CHM247H1/​ CHM249H1
  2. MSE219H1, ( MSE218H1/​ MSE318H1), MSE335H1
  3. CHM327H1, CHM338H1, CHM343H1/​ CHM348H1, CHM325H1/​ CHM355H1, CHM434H1/​ CHM455H1, CHM426H1/​ CHM457H1
  4. At least 1.5 credits from the following, of which 0.5 credit must be at the 400-level: MSE302H1, MSE316H1, MSE343H1, CHM446H1/​ CHM456H1, CHM458H1, MSE415H1, MSE419H1, MSE430H1, MSE431H1, ( MSE432H1/​ MSE443H1), MSE440H1, MSE458H1, MSE459H1, MSE461H1, MSE465H1
  5. CHM499Y1/​ ( MSE492H1, MSE493H1)

*It is highly recommended that students in the Materials Science Specialist Program complete MSE202H1.

Students in this program have the option to complete the Arts & Science Internship Program (ASIP) stream.

Pharmaceutical Chemistry Specialist (Science Program) - ASSPE1211

Consult Professor D. Dubins, Faculty of Pharmacy

The Pharmaceutical Chemistry Specialist Program combines knowledge of the biological, medical, and physical sciences in the study of the scientific aspects of drug therapy, with an emphasis placed on the chemical nature of the reactions and interactions involved in drug therapy. The program is offered jointly by the Department of Chemistry and the Leslie Dan Faculty of Pharmacy at the University of Toronto. Students in the Pharmaceutical Chemistry Specialist program will receive a solid background and training in physical, organic, and analytical chemistry, and will also learn the fundamental aspects of the synthesis, manufacture, use, and mode of action of drugs. This program provides excellent preparation for future work in the pharmaceutical industry and is accredited by Canadian Society for Chemistry,

Enrolment Requirements:

This is a limited enrolment program. Students must have completed 4.0 credits and meet the requirements listed below to enrol.

Variable Minimum Grade Average
A minimum grade average is needed for entry, and this minimum changes each year depending on available spaces and the number of applicants. The following courses must be completed:

BIO120H1 and BIO130H1
• ( CHM135H1 and CHM136H1)/ CHM151Y1
• ( PHY131H1 and PHY132H1)/( PHY151H1 and PHY152H1)

To ensure that students admitted to the program will be successful, applicants with a final grade lower than 60%, or a grade average lower than 70% will not be considered for admission. Please note that obtaining this minimum final grade or minimum grade average does not guarantee admission to the program.

Arts & Science Internship Program

Students in this program have the option to request enrolment in the Arts & Science Internship Program (ASIP) stream. Students can apply for the ASIP stream after Year 1 (Year 2 entry) or after Year 2 (Year 3 entry). Full details about ASIP, including student eligibility, selection and enrolment, are available in the ASIP section of the Arts & Science Academic Calendar. Please note that space is more limited for Year 3 entry and students applying for Year 3 entry must have been admitted to the Pharmaceutical Chemistry Specialist in the Summer after Year 2.

Completion Requirements:

(13.0 credits, including 1.0 credit from 400-level courses)

NOTE: Some of the courses listed below may have prerequisites.

First Year:

  1. BIO120H1, BIO130H1
  2. ( CHM135H1 and CHM136H1)/ CHM151Y1
  3. ( PHY131H1 and PHY132H1)/ ( PHY151H1 and PHY152H1)

Second Year:

  1. BCH210H1
  2. BIO230H1
  3. CHM220H1/​ CHM222H1, CHM223H1, ( CHM249H1 strongly recommended/ CHM247H1)
  4. PCL201H1
  5. PHC230H1

Third Year:

  1. CHM217H1
  2. PHC300H1, PHC301H1, PHC320H1, PHC330H1, PHC340Y1

Fourth Year:

  1. PHC489Y1/​ CHM499Y1/​ CHM395Y1
  2. 2.0 credits from: CHM317H1, CHM342H1, CHM347H1, CHM379H1, CHM410H1, CHM414H1, CHM417H1, CHM427H1, CHM440H1, JPM300H1, JPM400Y1, PCL362H1, PCL386H1, PHC331H1, PHC401H1, PHC420H1, PHC421H1, PHC430H1, PHC431H1, PHC432H1, PHC435H1, PHC460H1, PHC462H1, PHC470H1, PSL300H1, PSL301H1

Note that not all of the 400-level PHC courses are offered every academic year.

Synthetic & Catalytic Chemistry Specialist (Science Program) - ASSPE1377

Consult Professor R. Batey, Department of Chemistry.

This program focuses on the fundamentals and practical aspects of modern synthetic organic and inorganic chemistry, and the understanding and applications of catalytic reactions. Students will become exposed to extensive green chemistry approaches from both experimental and theoretical perspectives. The program provides preparation for career paths as synthetic/discovery chemists, in the pharmaceutical, biotechnology, biomedical, crop protection, materials and related sectors, or for academic research and teaching positions. This program is accredited by the Canadian Society for Chemistry.

Enrolment Requirements:

This is a limited enrolment program. Students must have completed 4.0 credits and meet the requirements listed below to enrol.

Completed courses (with minimum grades)
The following courses with the stated minimum grades are required:

• ( CHM135H1, CHM136H1) (63% in each)/ CHM151Y1 (63%)

Students in this program have the option to request enrolment in the Arts & Science Internship Program (ASIP) stream. Students can apply for the ASIP stream after Year 1 (Year 2 entry) or after Year 2 (Year 3 entry, starting Fall 2024). Full details about ASIP, including student eligibility, selection and enrolment, are available in the ASIP section of the Arts & Science Academic Calendar. Please note that the majority of students enter ASIP in Fall term of Year 2. Space is more limited for Year 3 entry. Students applying for Year 3 entry must have been admitted to the Synthetic & Catalytic Chemistry Specialist in the Summer after Year 2.

Completion Requirements:

(14.0 credits)

First Year: ( CHM151Y1 strongly recommended)/ ( CHM135H1, CHM136H1); ( MAT135H1, MAT136H1)/ MAT137Y1/​ MAT157Y1; ( PHY131H1, PHY132H1)/ ( PHY151H1, PHY152H1)

Second and Higher Years:

  1. BCH210H1, CHM217H1, ( CHM220H1/​ CHM222H1, CHM223H1), ( CHM236H1, CHM237H1)/ CHM238Y1, ( CHM249H1 strongly recommended)/ CHM247H1; MAT235Y1/​ MAT237Y1
  2. CHM317H1, CHM338H1, CHM342H1, CHM343H1, CHM347H1, CHM348H1
  3. CHM432H1, CHM440H1, CHM441H1, CHM443H1
  4. CHM395Y1/​ CHM499Y1/​ PHC489Y1 and/or CHM397H0/​ CHM398H0 in areas relevant to the program with prior approval by the Department
  5. Additional 300/400-level courses from CHM, which may include courses from among CHM325H1, CHM355H1/​ CHM328H1, CHM379H1, CHM416H1, CHM434H1/​ CHM455H1, CHM437H1, CHM447H1 and CHM479H1 to a total of 14.0 credits.

Students in this program have the option to complete the Arts & Science Internship Program (ASIP) stream.

Chemistry Major (Science Program) - ASMAJ1376

Consult Professor A. Dicks, Department of Chemistry.

The Chemistry Major Program provides exposure to the core areas of chemistry together with appropriate courses in mathematics during the first two years and allows students to follow a particular area or areas of interest during the third year and fourth year. The program is extremely flexible in its design in that students may focus their studies in the traditional sub-disciplines of inorganic, analytical, organic, or physical chemistry during the second year, and then progress to take upper-year courses in these areas or in additional sub-disciplines including biological, materials and environmental chemistry. Students gain extensive laboratory experience throughout the program from whichever path they choose to take.

Enrolment Requirements:

This is a limited enrolment program. Students must have completed 4.0 credits and meet the requirements listed below to enrol.

Completed courses (with minimum grades)
The following courses with the stated minimum grades are required:

• ( CHM135H1 and CHM136H1) (63% in each)/ CHM151Y1 (63%)

Completion Requirements:

(8.0 credits, including at least one 0.5 CHM credit at the 400-level)

First Year: ( CHM151Y1 strongly recommended)/( CHM135H1 and CHM136H1); ( MAT135H1 and MAT136H1)/ MAT137Y1/​ MAT157Y1

Second Year:

At least two of the following four options:

Third Year: At least two of CHM317H1, CHM327H1, CHM338H1, CHM343H1, CHM348H1, CHM379H1

Fourth Year: Additional 200/300/400-level CHM courses to a total of 7.0 credits ( CHM299H1, CHM299Y1, CHM396Y0, CHM397H0, CHM398H0, CHM398Y0, CHM399H1, CHM399Y1 excluded). Students may count either CHM395Y1 or CHM499Y1 towards Chemistry Major requirements.

Environmental Chemistry Major (Science Program) - ASMAJ2543

Consult Professor J. Murphy, Department of Chemistry

Environmental chemistry is the study of the chemical impacts of humankind’s activities on the soil, air, and water. This program focuses on the development of fundamental skills in instrumental and mechanistic chemical analysis that are required to understand the sources, fate, and impacts of both organic and inorganic contaminants in soil, air, water, and biological tissues. It involves a solid foundation in chemistry with specialized courses in environmental and analytical chemistry and contains flexibility for students to select additional courses in areas of study of most interest to them. Students may be interested in combining an Environmental Chemistry Major with other major programs such as Environmental Science, or programs in the life sciences offered by departments including Cell & Systems Biology and Ecology & Evolutionary Biology.

Enrolment Requirements:

This is a limited enrolment program. Students must have completed 4.0 credits and meet the requirements listed below to enrol.

Completed courses (with minimum grades)
The following courses with the stated minimum grades are required:

Completion Requirements:

(8.0 credits)

First Year:
1. ( CHM135H1, CHM136H1)/ CHM151Y1
2. ( MAT135H1, MAT136H1)/ MAT137Y1/​ MAT157Y1

Second Year:
3. CHM210H1, CHM217H1
4. ( CHM249H1 strongly recommended)/ CHM247H1
( CHM220H1/​ CHM222H1 is strongly recommended.)

Third Year:
5. CHM310H1
6. At least 1.0 credit from: CHM317H1, CHM327H1, CHM338H1, CHM343H1, CHM348H1, CHM379H1

Fourth Year:
7. CHM410H1 and CHM415H1

8. Additional 200/300/400-level CHM courses to a total of 7.0 CHM credits ( CHM299H1, CHM299Y1, CHM396Y0, CHM397H0, CHM398H0, CHM398Y0, CHM399H1, CHM399Y1 excluded)

Environmental Chemistry Minor (Science Program) - ASMIN2543

Consult Professor J. Murphy, Department of Chemistry

The Environmental Chemistry Minor program provides a balanced fundamental background in chemistry as well as an introduction to the major issues associated with environmental chemistry. This is achieved through a combination of introductory courses at the first and second-year levels, along with specific analytical and environmental chemistry courses in upper years.

Enrolment Requirements:

This is an open enrolment program. A student who has completed 4.0 credits may enrol in the program.

Completion Requirements:

(4.0 credits, including 1.0 credit at the 300+ level)

  1. ( CHM135H1, CHM136H1)/ CHM151Y1
  2. 1.0 credit from: CHM217H1, CHM220H1/​ CHM222H1, ( CHM236H1, CHM237H1)/ CHM238Y1, CHM247H1/​ CHM249H1
  3. CHM210H1
  4. CHM310H1, and 1.0 credit from: CHM317H1, CHM410H1, CHM415H1

Chemistry Minor (Science Program) - ASMIN1376

Consult Professor A. Dicks, Department of Chemistry.

The Chemistry Minor is an open-enrollment program that provides students with an opportunity to experience the different sub-disciplines in chemistry without the more significant commitment of enrolling in a specialist or major program. Students gain laboratory experience throughout the program in an area or areas of their choice (organic, inorganic, physical, biological, or analytical).

Enrolment Requirements:

This is an open enrolment program. A student who has completed 4.0 credits may enrol in the program.

Completion Requirements:

Consult Associate Chair, Undergraduate Studies, Department of Chemistry.

(4.0 credits, including 1.0 credit CHM course at the 300+ level)

First Year:

Second Year:

At least one of the following four options:

Third Year:

Fourth Year:

Focus in Green Chemistry

Consult Professor A. Dicks, Department of Chemistry.

The Focus in Green Chemistry provides students with the opportunity to emphasize green chemistry as part of any chemistry specialist or major program they are enrolled in. An understanding of green chemistry principles is integral to meeting several of the United Nations Sustainable Development Goals (SDGs: https://www.un.org/sustainabledevelopment/sustainable-development-goals), particularly those centered around affordable energy, climate action, clean water and sanitation, responsible consumption and production, and good well-being. As such, green chemistry broadly concerns the design and redesign of products and processes to reduce their impact on human health and the environment. This focus will be attractive to students who wish to combine courses that cover principles of toxicology, reaction metrics, safer chemicals/solvents, pollution prevention/recycling, catalysis, and energy efficiency.

Enrolment Requirements:

Enrolment in one of the following programs is required:

  • Chemistry Major (Focus ASFOC1376A)
  • Chemistry Specialist (Focus ASFOC1376B)
  • Biological Chemistry Specialist (Focus ASFOC1995A)
  • Synthetic & Catalytic Chemistry Specialist (Focus ASFOC1377A)
  • Pharmaceutical Chemistry Specialist (Focus ASFOC1211A)
  • Chemical Physics Specialist (Focus ASFOC0600A)
  • Materials Science Specialist (Focus ASFOC2424A)
  • Environmental Chemistry Major (Focus ASFOC2543A)
Completion Requirements:

Focus in Practical Chemical Analysis

Consult Professor D. Stone, Department of Chemistry.

The Focus in Practical Chemical Analysis provides students with the opportunity to emphasize chemical detection, identification, and measurement in a laboratory setting as part of any chemistry specialist or major program they are enrolled in. Having experience with and an understanding of methods for chemical analysis is of considerable value for both potential employers and students pursuing postgraduate research. Chemical analysis has wide application in fields as diverse as alternative energy and storage solutions; clinical medicine and research; drinking water quality and regulatory compliance; environmental monitoring and remediation; food quality and safety; pharmaceutical development, testing, and quality assurance; and product manufacturing and quality control.

Enrolment Requirements:

Enrolment in one of the following programs is required:

  • Chemistry Specialist - ASSPE1376 (Focus Code: ASFOC1376D)
  • Biological Chemistry Specialist - ASSPE1995 (Focus Code: ASFOC1995B)
  • Pharmaceutical Chemistry Specialist - ASSPE1211 (Focus Code: ASFOC1211B)
  • Materials Science Specialist - ASSPE2424 (Focus Code: ASFOC2424B)
  • Synthetic & Catalytic Chemistry Specialist - ASSPE1377 (Focus Code: ASFOC1377B)
  • Chemical Physics Specialist - ASSPE0600 (Focus Code: ASFOC0600B)
  • Chemistry Major - ASMAJ1376 (Focus Code: ASFOC1376C)
  • Environmental Chemistry Major - ASMAJ2543 (Focus Code: ASFOC2543C)
Completion Requirements:

Completion of the Focus in Practical Chemical Analysis requires the following 2.5 credits:

  1. CHM217H1
  2. CHM317H1 (students in ASSPE1211 may use PHC340Y1)
  3. Additional courses to a total of 2.5 credits from: CHM338H1, CHM343H1, CHM379H1, CHM410H1, and CHM441H1. CHM395Y1 or CHM499Y1 may be used to fulfil this requirement with the permission of the department.

Chemistry Courses

CHM101H1 - The Chemistry and Biology of Organic Molecules: Sex, Drugs and Rock and Roll!

Hours: 30L/6T

An introduction to chemistry and chemical principles for non-scientists, with a focus on the chemistry and biology of organic molecules. The myriad roles these compounds play in our lives are discussed, including their use of pheromones, medicines and weapons, and their effect on colour, taste and smell.

Breadth Requirements: The Physical and Mathematical Universes (5)

CHM135H1 - Chemistry: Physical Principles

Hours: 36L/12T/18P

CHM135H1 and CHM136H1 cannot be taken in the same session.

Structure of matter, gases, liquids and solids; phase equilibria and phase diagrams; colligative properties; chemical equilibria; electrolyte solutions and electrochemistry; reaction kinetics; introduction to thermodynamics. Recommended for students in life and health science programs that involve a small amount of chemistry. (Lab Materials Fee: $26).

Prerequisite: Chemistry SCH4U, Mathematics MHF4U + MCV4U
Corequisite: ( MAT135H1, MAT136H1)/ MAT137Y1/ MAT157Y1 recommended but may be required for further Chemistry courses

Exclusion: CHM151Y1, CHMA11H3, CHM110H5
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM136H1 - Introductory Organic Chemistry I

Hours: 36L/12T/18P

CHM135H1 and CHM136H1 cannot be taken in the same session.

An introduction to principles of structure and their relation to reactivity of organic molecules: molecular structure, stereochemistry, functional groups, reactions, and mechanisms. Recommended for students in life and health science programs that involve a small amount of chemistry. (Lab Materials Fee: $26).

Prerequisite: CHM135H1
Corequisite: ( MAT135H1, MAT136H1)/ MAT137Y1/ MAT157Y1 recommended but may be required for further Chemistry courses
Exclusion: CHM151Y1, CHM242H5, CHMB41H3
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM151Y1 - Chemistry: The Molecular Science

Hours: 72L/24T/35P

An introduction to the major areas of modern chemistry, including organic and biological chemistry; inorganic/materials chemistry and spectroscopy; and physical chemistry/chemical physics. The course is highly recommended for students who plan to enrol in one of the chemistry specialist programs, or who will be including a substantial amount of chemistry in their degree (such as those following a chemistry major or minor program). The combination of CHM151Y1 and CHM249H1 serves as a full year introductory course in organic chemistry with laboratory. (Lab Materials Fee: $39).

Note: CHM151Y1 has a unique Course Community where the undergraduate experience in chemistry is greatly enhanced through a series of workshops, research seminars, tours, outreach opportunities and social activities. 90-minute biweekly Course Community meetings are held during laboratory class hours during alternate weeks to the laboratory sessions. The lab time is reserved for CHM151Y1 activities every week of each semester.

Prerequisite: Chemistry SCH4U, Mathematics MHF4U + MCV4U; Physics SPH4U recommended
Corequisite: ( MAT135H1, MAT136H1)/ MAT137Y1/ MAT157Y1; ( PHY131H1, PHY132H1)/ ( PHY151H1, PHY152H1) recommended, but may be required for further Chemistry courses
Exclusion: CHM135H1, CHM136H1, CHMA10H3, CHMA11H3, CHMB41H3, CHM110H5, CHM120H5
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM193H1 - Chemicals in the Environment: The Good, the Bad, and the Ugly

Previous Course Number: CHM211H1

Hours: 24S

The world is made up of chemicals: some are natural and some are invented and manufactured by humans. New chemicals are often intended to make our lives safer and easier (e.g., plastics, pesticides, personal care products) but may have unanticipated consequences once they are released into the world. In this seminar course, students will discover what properties of chemicals can lead to risks for the environment and for human health. Through discussion of how chemicals in the environment are understood by scientists, and described in popular media, students will develop improved scientific literacy to better evaluate risk in their own lives. Restricted to first-year students. Not eligible for CR/NCR option.

Exclusion: CHM211H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM194H1 - Science and Human Values

Hours: 24S

There is a tension between creativity and the search for truth, which in science can be looking for patterns in nature. With examples drawn particularly from reports of scientific discoveries that have generated controversy, this seminar course will introduce the underlying principles and history of science, as well as how science and its boundaries are evolving, and how these influence human values. Restricted to first-year students. Not eligible for CR/NCR option.

Recommended Preparation: Minimum level of high school science and mathematics
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM196H1 - The Quantum World and Its Classical Limit

Hours: 24S

This course seeks to demystify quantum mechanics and equip students to critically analyze popular depictions of quantum phenomena. While quantum mechanics provides a reliable description of the behavior of atoms, molecules and photons, most people are uncomfortable with some of its predictions, such as "quantum entanglement" between distant particles. In this course we will delve into key aspects of quantum mechanics and its more comfortable classical limit, focusing first on its manifestations in nature and then on fundamental issues such as uncertainty, interference, entanglement, and decoherence. This course will appeal to students with enthusiasm for physics. Restricted to first-year students. Not eligible for CR/NCR option.

Recommended Preparation: High school physics and mathematics
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM197H1 - Environmental Chemistry in a Sustainable World

Hours: 24S

Rapid and widespread industrialization is changing the chemical nature of the planet. In order to have a sustainable future, we need to manage chemicals released by humankind and understand their effects on the environment and on us. Each year, this seminar course designed for non-science students will address the fundamental science behind a specific topic in this field, such as the interactions of our energy choices and the environment, or changes in water and air quality. Emphasis is given to reading from both the popular media and scientific literature. Restricted to first-year students. Not eligible for CR/NCR option.

Recommended Preparation: Grade 12 chemistry
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM198H1 - Biosensor Technology and Applications for the Non-Scientist

Hours: 24S

This breadth course introduces uses of and key ideas behind biosensor technology. Sensors will be familiar to all, playing key roles in our everyday lives, for example in touch screens or in automotive technology. Biosensor devices are fabricated from an electrical transducer which is intimately connected to a biochemical probe such as an enzyme or antibody. The idea is that a detectable electrical signal can be obtained when a target molecule or ion binds to the probe. Such a device offers many applications. These range from the detection of biological markers in blood and serum to test for genetic and infectious disease, to the selective monitoring of biomolecules for public safety, or in biotechnology or other industrial processes. Restricted to first-year students. Not eligible for CR/NCR option.

Recommended Preparation: Reading of book chapter on biosensor technology
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM199H1 - The Context of Chemistry: Origins, Concepts, Tools, and Challenges

Hours: 24S

Chemistry is a practical as well as a conceptual science that serves as the basis for applications in many other fields. The ideas and methods have evolved from diverse inputs leading to widely accepted sets of standard of facts. This collective knowledge has led to progress in the quality and understanding of life at a molecular level. While the facts of chemistry are taught in established courses, the context of what we know, the limitations and challenges of what chemistry can do and how we got to this point will be the targets for discovery by students in this course. The course will operate in a seminar model, combining presentations, readings, reports and discussions of current and historical issues. Restricted to first-year students. Not eligible for CR/NCR option.

Recommended Preparation: Grade 12 level chemistry
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM209H1 - Science of the Modern Kitchen

Hours: 24L

The properties of different food types will be discussed, as well as how they can be manipulated in the kitchen to transform taste and texture. Concepts will be considered through the lens of the scientific method, and many of the ingredients and practices of modernist cuisine will be examined. This course is intended for students with no science background.

Exclusion: CHM135H1/ CHM136H1/ CHM138H1/ CHM139H1/ CHM151Y1
Recommended Preparation: SCH4U
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM210H1 - Chemistry of Environmental Change

Hours: 24L/12T

This course examines the fundamental chemical processes of the Earth’s natural environment, and changes induced by human activity. Topics covered are related to the atmosphere and the hydrosphere: urban air pollution, stratospheric ozone depletion, acid rain, climate change, water resources and pollution, wastewater analysis, biogeochemistry, and inorganic metals in the environment. Skills in data analysis and visualization will be developed through an introduction to the R programming language and its use in several assignments.

Prerequisite: ( CHM135H1/ CHM151Y1), ( MAT135H1/ MAT137Y1/ MAT157Y1)
Exclusion: ENV235Y1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM217H1 - Introduction to Analytical Chemistry

Hours: 30L/6T/52P

Introduction to the science of chemical measurement, from sampling through analysis to the interpretation of results, including how water, food products, pharmaceuticals, and dietary supplements are analysed for content, quality, and potential contaminants. Also how to interpret experimental measurements, compare results and procedures, and calibrate analytical instrumentation. Through closely integrated classes, laboratories, and tutorials, this highly practical course introduces a variety of analytical techniques including volumetric methods, potentiometry, uv/visible and infrared spectrophotometry, flame atomic absorption spectrometry, and chromatography. Additional information can be found at http://www.chem.utoronto.ca/coursenotes/CHM217/. (Lab Materials Fee: $39).

Prerequisite: ( CHM135H1, CHM136H1)/ CHM151Y1 with a minimum grade of 63%, ( MAT135H1, MAT136H1)/ MAT137Y1/ MAT157Y1
Exclusion: CHM211H5, CHMB16H3
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM220H1 - Physical Chemistry for Life Sciences

Hours: 36L/12T

Introduction to thermodynamics; kinetics; phase equilibrium, properties of mixtures, chemical equilibrium, electrochemistry; introduction to quantum mechanics and spectroscopy. This course is recommended for students in life and health science programs that involve a small amount of chemistry.

Prerequisite: ( CHM135H1, CHM136H1)/ CHM151Y1; ( MAT135H1, MAT136H1)/ MAT137Y1/ MAT157Y1
Corequisite: Recommended co-requisite: MAT235Y1/ MAT237Y1
Exclusion: CHM222H1, CHMB20H3, JCP221H5/ CHM221H5
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM222H1 - Introduction to Physical Chemistry

Hours: 24L/12T

Topics: introductory thermodynamics, first and second law and applications; chemical equilibrium. The course is intended for students who will be following the majority of chemistry specialist programs (Biological Chemistry specialist students are highly recommended to take CHM220H1).

Prerequisite: [( CHM135H1, CHM136H1)/ CHM151Y1 with a minimum grade of 63%], ( MAT135H1, MAT136H1)/ MAT137Y1/ MAT157Y1, ( PHY131H1, PHY132H1)/ ( PHY151H1, PHY152H1)
Corequisite: MAT235Y1/ MAT237Y1 recommended
Exclusion: CHM220H1, CHMB20H3, CHM221H5, JCP221H5
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM223H1 - Physical Chemistry: The Molecular Viewpoint

Previous Course Number: CHM221H1

Hours: 24L/12T

CHM223H1 introduces key concepts and mathematical approaches that underly fundamental quantum mechanical models of atoms and molecules. Connections are drawn between these microscopic models and macroscopic properties of systems in physical chemistry—both how experimental observations shape the chosen structure of the models, and how these models can now successfully predict and interpret the results of experiments.

Prerequisite: CHM220H1 with a minimum grade of 63%/ CHM222H1
Corequisite: MAT235Y1/ MAT237Y1 recommended
Exclusion: CHMB21H3
Breadth Requirements: The Physical and Mathematical Universes (5)

PHC230H1 - Pharmaceutics 1

Hours: 36L/12T

This course introduces the key concepts in the design, manufacture, and use of efficacious dosage forms. The characteristics of different delivery routes are discussed. The course focuses on the role of pharmaceutics in drug development, and the role of anatomy and physiology in the conception and design of effective dosage forms. Topics covered include biopharmaceutical considerations, pharmaceutical solutions, sterilization theories and techniques, complexation and solubility enhancement, pre-formulation, colloids and dispersions, powders and micromeritics, and solid-state properties. Students will gain an appreciation of how the properties of drug components (such as pH, salt concentration, co-solvents, sterility, colloids, dispersions, powders, and solids) determine the stability, solubility, and efficacy of drug products.

Prerequisite: ( CHM135H1 and CHM136H1)/ CHM151Y1; CHM220H1/ CHM222H1
Exclusion: PHM141H1
Breadth Requirements: Living Things and Their Environment (4)

CHM236H1 - Introductory Inorganic Chemistry I

Hours: 24L/12T

Inorganic chemistry is the chemistry of all the periodic table elements and includes the synthesis of the largest volume chemicals on Earth, the key energy-generating reactions and catalysts needed for a green planet, and compounds exploited in modern electronic and photonic devices. This is the first part (followed by CHM237H1 and then CHM338H1) of a two-year sequence illustrating the rich variety of structures, physical properties, and reactions of compounds of the elements across and down the periodic table. It includes fundamentals of bonding, symmetry, and acid-base/ redox reactions of molecular compounds and transition metal complexes and applications of this chemistry in the world. CHM236H1 is recommended for students interested in broadly learning about chemistry across the periodic table.

Prerequisite: CHM151Y1/( CHM135H1, CHM136H1) with a minimum grade of 63%
Exclusion: CHM231H5, CHM238Y1, CHMB31H3
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM237H1 - Introductory Inorganic Chemistry II

Hours: 24L/6T/48P

This course is a continuation from CHM236H1 which further studies the chemistry of the elements across the periodic table. It will cover topics that include the periodic properties of the elements, the structures, bonding and properties of main group compounds and transition metal complexes, inorganic solid-state materials, and solid-state chemistry with applications in advanced technologies. A strong emphasis on developing laboratory techniques and communication skills is made through the practical component of the course. CHM236H1 is strongly recommended for students exploring experimental synthetic chemistry as part of their degree program. (Lab Materials Fee: $39)

Prerequisite: CHM236H1 with a minimum grade of 63%
Exclusion: CHM231H5, CHM238Y1, CHMB31H3
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM247H1 - Introductory Organic Chemistry II

Hours: 36L/12T/22P

Reactions of organic compounds. Principles of mechanism, synthesis, and spectroscopy, continuing from CHM136H1. This course is recommended for students in life and health science programs that involve a small amount of chemistry. Students who will be including a substantial amount of chemistry in their degree (including those following a chemistry major program) are strongly encouraged to take CHM249H1. (Lab Materials Fee: $26).

Prerequisite: ( CHM135H1, CHM136H1)/ CHM151Y1
Exclusion: CHM249H1, CHM243H5, CHMB42H3
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM249H1 - Organic Chemistry

Hours: 36L/52P

An introductory course in organic chemistry, based around the themes of structure, bonding, reaction mechanism, and synthesis. Reactions are discussed with a view to understanding mechanisms and how they are useful in the multi-step synthesis of medicinally and industrially important compounds. An introduction to the spectroscopy of organic molecules is also given, as well as a discussion of topics relating to the biological behaviour of organic molecules and medicinal chemistry. Students are also introduced to green chemistry approaches from an experimental perspective. This course continues from CHM151Y1 or CHM136H1 and is designed for students enrolled in any chemistry specialist or major program. (Lab Materials Fee: $39).

Prerequisite: CHM151Y1/ ( CHM135H1, CHM136H1) with a minimum grade of 63%
Exclusion: CHM247H1, CHM243H5, CHMB42H3
Breadth Requirements: The Physical and Mathematical Universes (5)

JCC250H1 - Computing for Science

Previous Course Number: CSC198H1

Hours: 24L/24T

Computational skills for the modern practice of basic and applied science. Applied computer programming with an emphasis on practical examples related to the simulation of matter, drawing from scientific disciplines including chemistry, biology, materials science, and physics. Studio format with a mixture of lecture, guided programming, and open scientific problem solving. Students will be exposed to Python numerical and data analysis libraries. No prior programming experience is required.

Prerequisite: CHM135H1/ CHM136H1/ CHM151Y1, 0.5 credit in MAT (excluding FYF courses)
Exclusion: Any CSC course except CSC104H1, CSC196H1, CSC197H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM295H1 - Research Experience in Chemistry

Hours: 12L/48P

A course-based undergraduate research experience (CURE) that will introduce students to experimental research in chemistry from a physical science perspective, involving measurement, use of scientific instruments, and data analysis. Students will collaborate in teams to acquire research skills by carrying out laboratory work on a specific project that is defined by various chemistry departmental research groups. The topics will cover a range of research areas; however the approach will include aspects of physical chemistry such as spectroscopy, thermodynamics, nanotechnology, properties of materials, and reaction kinetics. Training in the use of instruments and data acquisition and analysis will be provided.

Prerequisite: ( CHM135H1, CHM136H1)/ CHM151Y1, ( MAT135H1, MAT136H1)/ MAT137Y1/​ MAT157Y1), ( PHY131H1, PHY132H1)/ ( PHY151H1, PHY152H1)
Corequisite: CHM220H1/ CHM222H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM299H1 - Research Opportunity Program

Credit course for supervised participation in faculty research project. Details at https://www.artsci.utoronto.ca/current/academics/research-opportunities/research-opportunities-program. Not eligible for CR/NCR option.

CHM299Y1 - Research Opportunity Program

Credit course for supervised participation in faculty research project. Details at https://www.artsci.utoronto.ca/current/academics/research-opportunities/research-opportunities-program. Not eligible for CR/NCR option.

PHC300H1 - Molecular Pharmacology 1

Hours: 24L/12T

Structural and mechanistic determinants of drug action at the molecular level. Topics include the physical-chemical properties of drugs per se as they relate to therapeutic intervention and the biophysical and biochemical properties of enzymes and nucleic acids that underlie and are affected by their interactions with drugs.

Prerequisite: ( CHM135H1, CHM136H1)/ CHM151Y1; CHM220H1/ CHM222H1
Exclusion: PCL302H1
Breadth Requirements: Living Things and Their Environment (4)

JSC301H1 - Principles and Practices in Science Education

Hours: 24L

Fundamental principles and practices in education and public outreach in the sciences, mathematics, and engineering, including education research, curriculum, teaching, and assessment.  Students will learn and apply effective strategies which engage and educate learners at the K-16 and public level.  The course assignments include a project and/or placement experience.

Prerequisite: At least 8.0 credits, and enrolment in a science, mathematics, or engineering program
Breadth Requirements: Society and its Institutions (3)

PHC301H1 - Molecular Pharmacology 2

Hours: 36L/12T

Structural and mechanistic determinants of drug action via macromolecules that effect cellular signalling. Neurohumoral receptors and other signalling proteins are grouped according to their structure and mechanism of action. Native properties and their modulation by drugs are discussed in the context of basic principles of molecular pharmacology.

Prerequisite: ( CHM135H1, CHM136H1)/ CHM151Y1; CHM220H1/ CHM222H1; BCH210H1
Exclusion: PCL302H1, PHM140H1
Breadth Requirements: Living Things and Their Environment (4)

CHM310H1 - Environmental Fate and Toxicity of Organic Contaminants

Hours: 24L/12T

Organic chemical contaminants surround us in our everyday lives (e.g. in medications, personal care products, flame retardants, refrigerants) and because of this, they are present in the environment and in ourselves. In this course we will explore the fate of chemicals in the environment as a whole, as well as in the body, to understand how chemicals can be designed to mitigate the risks associated with their use and unintended release. Specific topics will include environmental partitioning; environmentally-relevant transformation processes; the chemistry and effects of redox-active species; and the toxicity/detoxification of electrophilic species in the body. Skills in big data analysis and environmental modeling will be developed through an introduction to the R programming language at the beginner level.

Prerequisite: ( CHM135H1, CHM136H1)/ CHM151Y1, ( MAT135H1, MAT136H1)/ MAT137Y1/ MAT157Y1
Recommended Preparation: CHM247H1/ CHM249H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM317H1 - Introduction to Instrumental Methods of Analysis

Hours: 24L/52P

Scope of instrumental analytical chemistry; Fourier transform IR absorption spectroscopy; molecular luminescence; emission spectroscopy; mass spectrometry; sensors; gas and high performance liquid chromatography; instrument design principles and applications in industry and the environment. (Lab Materials Fee: $39).

Prerequisite: CHM217H1 with a minimum grade of 63%; ( MAT135H1, MAT136H1)/ MAT137Y1/ MAT157Y1
Exclusion: CHM391H5, CHMC11H3, CHMC16H3
Recommended Preparation: CHM220H1/ CHM222H1, CHM223H1
Breadth Requirements: The Physical and Mathematical Universes (5)

PHC320H1 - Chemistry and Technologies in Drug Discovery

Hours: 36L

This course provides interdisciplinary learning related to the chemistry of drugs and technologies of drug discovery as they are related to small molecules and biologics, their mechanisms of action, and the latest trends in the field of pharmaceuticals. Various important concepts such as structure-activity relationships, drug-like properties, computer modelling, combinatorial chemistry, small molecule drugs, biologics and related aspects in relation to new drugs will be covered. Novel concepts such as artificial intelligence in drug discovery will be introduced. After completing this course, students may practice entry-level medicinal chemistry with sound synthetic chemistry acquired from other chemistry courses, or take advanced courses in medicinal chemistry, drug discovery, and specialized courses in drug development. Students will also have a deeper understanding of drug discovery and development.

Prerequisite: BCH210H1, CHM247H1/ CHM249H1
Breadth Requirements: Living Things and Their Environment (4)

CHM326H1 - Introductory Quantum Mechanics and Spectroscopy

Hours: 24L/12T

This course introduces the postulates of quantum mechanics to develop the fundamental framework of quantum theory. A number of exactly soluble problems are treated in detail as examples. Perturbation theory is introduced in the context of understanding many body problems. Various applications to chemical bonding and molecular spectroscopy are covered in detail.

Prerequisite: ( CHM220H1/ CHM222H1, CHM223H1), MAT235Y1/ MAT237Y1
Exclusion: JCP321H5, PHY356H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM327H1 - Experimental Physical Chemistry

Hours: 12L/52P

Students are introduced to physical chemistry laboratory work in a project-based approach in which they develop, design, and implement projects that address fundamental and applied questions in physical chemistry. The course also involves class material related to working as an experimental physical chemist. (Lab materials fee: $39).

Prerequisite: ( CHM220H1/ CHM222H1/ MSE202H1, CHM223H1) with a minimum grade of 63% in each
Corequisite: Recommended: CHM326H1 or CHM328H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM328H1 - Modern Physical Chemistry

Hours: 24L/12T

This course explores the microscopic description of macroscopic phenomena in chemistry. Statistical mechanics is introduced as the bridge between the microscopic and macroscopic views, and applied to a variety of chemical problems including reaction dynamics. More advanced topics in thermodynamics are introduced and discussed as required.

Prerequisite: ( CHM220H1/ CHM222H1, CHM223H1), MAT235Y1/ MAT237Y1
Exclusion: JCP322H5, CHMC20H3
Breadth Requirements: The Physical and Mathematical Universes (5)

PHC330H1 - Pharmaceutics 2

Hours: 36L/12T

This course provides an understanding of advanced topics in pharmaceutics. It involves a detailed examination of the material properties of pharmaceuticals and the role of cellular processes in the delivery of a drug to its site of action. Selected topics include thermodynamic characterization of drug solubility, diffusion measurement and its use in pharmaceutics, liposomal drug delivery, excipient consideration and selection for liquid dosage forms, polymeric materials in pharmaceutical applications, rheology and its applicability to liquid drug vehicles, bioequivalence determination of dermatological dosage forms, and an introduction on the impact of physiochemical properties on dermatological dosage forms.

Prerequisite: ( CHM135H1, CHM136H1)/ CHM151Y1; CHM220H1/ CHM222H1
Breadth Requirements: Living Things and Their Environment (4)

PHC331H1 - Establishing the Bioequivalence of Pharmaceutical Products

Hours: 48L

This course will introduce the practical and regulatory design elements and consideration of human clinical trials for the purposes of demonstrating bioequivalence between drug products. The principles discussed are currently used by generic and innovator drug companies in many countries. Students will learn about the regulations, methods, techniques, pharmacokinetics, and biostatistics involved in creating bioequivalence studies. The course has a heavy mathematical emphasis, with a large component dedicated to mathematical modeling (non-compartmental and compartmental pharmacokinetic modeling, and biostatistics). Also discussed are clinical trial sample size determination, bioequivalence study design elements, clinical study protocol and final report writing, disaster recovery and outlier analysis, and design of steady-state studies. A module is also included on developing and improving interview skills. After taking this course, students will understand the steps required to set up single-dose and steady-state pilot and pivotal bioequivalence trials using parallel, crossover, and semi-replicate designs, and be well-poised for entry-level scientific positions in industry.

Prerequisite: BCH210H1, CHM247H1/ CHM249H1, ( MAT135H1, MAT136H1)/ MAT137Y1, PHC230H1, PHC330H1
Breadth Requirements: Living Things and Their Environment (4)

CHM338H1 - Intermediate Inorganic Chemistry

Hours: 24L/52P

Further study of the structures, physical properties, and reactions of transition metals. Introductions to spectroscopy, structural analysis, reaction mechanisms, d-block organometallic compounds, applications of metal, and main group compounds in catalysis. The weekly laboratory explores advanced synthetic and spectroscopic techniques including air- and moisture-sensitive chemistry and multinuclear NMR spectroscopy, with a strong emphasis on developing scientific communication skills. (Lab Materials Fee: $39).

Prerequisite: CHM236H1 + CHM237H1 with a minimum grade of 63% in each course.
Exclusion: CHM331H5
Recommended Preparation: CHM217H1, CHM247H1/ CHM249H1
Breadth Requirements: The Physical and Mathematical Universes (5)

PHC340Y1 - Pharmaceutical Chemistry Laboratory

Hours: 24L/96P

This course will introduce students to theoretical and applied concepts in pharmaceutical chemistry, in research, development, and manufacturing contexts. The course is designed with lectures and laboratories covering major areas in pharmaceutical chemistry, which have been carefully scheduled together to link concepts discussed during lectures to practical hands-on activities. The course covers selected topics pertinent to drug development such as acid/base equilibria, buffer preparation, drug solubility, drug polymorphs and salt selection, pKa, and co-solvency. The course also examines characterizing properties of common liquid, semi-solid and solid drug vehicles, such as viscosity, degradation kinetics/stability, diffusivity, tonicity, particle size distribution, and powder flowability. Emphasis is placed on the process of drug manufacture. Laboratory equipment used is commonly found in formulation labs, pharmacies, pharmaceutical research laboratories, and pharmaceutical manufacturing facilities. A lecture module on ethics and academic integrity will discuss cutting-edge applications of ethics in research, and issues arising when complex scientific solutions are proposed to regulatory bodies and to the public eye.

Prerequisite: CHM247H1/ CHM249H1; ( CHM220H1/ CHM222H1), CHM223H1; BCH210H1
Breadth Requirements: Living Things and Their Environment (4)

CHM342H1 - Modern Organic Synthesis

Hours: 24L/12T

An overview of the preparation of various classes of organic compounds. Strategies and tactics of synthetic organic chemistry using examples from natural products and pharmaceuticals. C-C bond formation, functional group reactivity, structure, stereochemistry and selectivity.

Prerequisite: CHM247H1/ CHM249H1
Exclusion: CHM345H5
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM343H1 - Organic Synthesis Techniques

Hours: 24L/52P

This laboratory course showcases modern organic synthesis techniques and introduces chemical research principles. It provides excellent preparation for a CHM499Y1 project in organic chemistry. Associated classes teach theory and problem-solving approaches from a practical perspective and through industrial case studies. Green chemistry decision-making is a central theme of both the class and laboratory components. (Lab Materials Fee: $39).

Prerequisite: CHM247H1/ CHM249H1 with a minimum grade of 63%
Exclusion: CHM393H5
Recommended Preparation: CHM342H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM347H1 - Organic Chemistry of Biological Compounds

Hours: 24L/12T

An organic chemical approach to the structure and reactions of major classes of biological molecules: carbohydrates, amino acids, peptides and proteins, phosphates, lipids, heterocycles, vitamins, nucleotides, and polynucleotides. This is achieved through studies of advanced stereochemistry, chemical modification, reactions, and synthesis. In addition to classes and reading from texts, there will be opportunities for independent written assignments on several of the topics.

Prerequisite: CHM247H1/ CHM249H1
Exclusion: CHM347H5, CHMC47H3
Recommended Preparation: CHM217H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM348H1 - Organic Reaction Mechanisms

Hours: 24L/26P

Principles and methods of analyzing and predicting organic chemical reactivity: advanced stereochemistry, conformational analysis, molecular orbitals, reaction kinetics, isotope effects, linear free energy relationships, orbital transformations, systematization of mechanisms. The laboratory section is used to illustrate the operation of the principles, including examples of data acquisition for mechanistic analysis and theoretical computations. Regular original reports on methods and outcomes are an important part of the laboratory. (Lab Materials Fee: $26).

Prerequisite: CHM247H1/ CHM249H1 with a minimum grade of 63%
Exclusion: CHM341H5, CHMC41H3
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM355H1 - Introduction to Inorganic and Polymer Materials Chemistry

Previous Course Number: CHM325H1

Hours: 24L

Fashioned to illustrate how inorganic and polymer materials chemistry can be rationally used to synthesize superconductors, metals, semiconductors, ceramics, elastomers, thermoplastics, thermosets and polymer liquid crystals, with properties that can be tailored for applications in a range of advanced technologies. Coverage is fairly broad and is organized to crosscut many aspects of the field.

Prerequisite: CHM220H1/ CHM222H1, ( CHM236H1, CHM237H1), CHM247H1/ CHM249H1
Exclusion: CHM325H1, CHM426H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM379H1 - Biomolecular Chemistry

Hours: 24L/52P

This course provides an opportunity to learn core techniques in biological chemistry in a small group laboratory setting. It provides excellent preparation for a CHM499Y1 project in biological chemistry or related areas. Classes will discuss the theory behind the techniques and highlight how they are used in modern biological chemistry research and practice. Note: CHM379H1 can be used as the biochemistry lab requirement for students completing double majors in chemistry and biochemistry. (Lab Materials Fee: $39).

Prerequisite: ( CHM247H1/ CHM249H1 with a minimum grade of 63%), CHM347H1, BCH210H1
Exclusion: BCH370H1, CHM371H5
Recommended Preparation: CHM217H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM395Y1 - Research Project in Chemistry

Hours: 180P

An independent research project conducted under the direction of a teaching faculty or research faculty member in the Department during March (for Summer Session projects) and during July/August (for Fall/Winter Session projects): the application form is available at the Department of Chemistry website. Not eligible for CR/NCR option.

Prerequisite: Completion of at least 2.0 CHM credits with a minimum cGPA of 3.0 in all CHM credits. Students are required to identify a potential faculty supervisor before contacting the Associate Chair, Undergraduate Studies for enrolment permission. Written confirmation is needed from both the Associate Chair, Undergraduate Studies and the prospective supervisor. Attendance at a mandatory safety orientation training session held during the first week of May (Summer Session projects) or September (Fall/Winter Session projects).
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM396Y0 - Research Topic Abroad

Course credit for research or field studies abroad under the supervision of a faculty member. Not eligible for CR/NCR option.

Prerequisite: At least 8.5 credits and no more than 14.0 credits, including at least 1.5 credits from 200-level Chemistry courses, or permission of the instructor.
Recommended Preparation: CHM299Y1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM397H0 - Research Abroad in Chemistry

Independent research project in Chemistry under the supervision by a faculty member in an approved partner institution. This unique opportunity to conduct a lab-based research project is open to students in any Chemistry programs. Not eligible for CR/NCR option.

Prerequisite: Any CHM 300-level courses with lab; permission of the Department
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM398H0 - Research Excursions

An instructor-supervised group project in an off-campus setting. Details at https://www.artsci.utoronto.ca/current/academics/research-opportunities/research-excursions-program. Not eligible for CR/NCR option.

CHM398Y0 - Research Excursions

An instructor-supervised group project in an off-campus setting. Details at https://www.artsci.utoronto.ca/current/academics/research-opportunities/research-excursions-program. Not eligible for CR/NCR option.

CHM399H1 - Research Opportunity Program

Credit course for supervised participation in faculty research project. Details at https://www.artsci.utoronto.ca/current/academics/research-opportunities/research-opportunities-program. Not eligible for CR/NCR option.

PHC401H1 - Drug Transport across Biological Membranes

Hours: 24L

The goal of this course is to provide students with knowledge of the molecular processes involved in drug transport across biological cell membranes with emphasis on their physiological and clinical significance. This course is restricted to Pharmaceutical Chemistry Specialist program students.

Prerequisite: PHC301H1, and enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Corequisite: PHC300H1
Exclusion: JFK1122H
Breadth Requirements: Living Things and Their Environment (4)

CHM410H1 - Analytical Environmental Chemistry

Hours: 24L/44P

An analytical theory, instrumental, and methodology course focused on the measurement of pollutants in soil, water, air, and biological tissues and the determination of physical/chemical properties including vapour pressure, degradation rates, partitioning. Lab experiments involve application of theory. (Lab Materials Fee: $39).

Prerequisite: CHM217H1, CHM210H1/ CHM310H1
Recommended Preparation: CHM317H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM414H1 - Biosensors and Chemical Sensors

Hours: 24L

The development, design, and operation of biosensors and chemical sensors, including: biosensor technology, transducer theory and operation, device design and fabrication, surface modification and methods of surface analysis, flow injection analysis and chemometrics.

Prerequisite: CHM217H1/ CHM220H1/ CHM222H1
Recommended Preparation: CHM317H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM415H1 - Topics in Atmospheric Chemistry

Hours: 24L

Building upon the introductory understanding of atmospheric chemistry provided in CHM210H1, this course develops a quantitative description of chemical processes in the atmosphere. Modern research topics in the field are discussed, such as aerosol chemistry and formation mechanisms, tropospheric organic chemistry, the chemistry of climate including cloud formation and geoengineering, biosphere-atmosphere interactions, and the chemistry of remote environments. Mathematical models of atmospheric chemistry are developed; reading is from the scientific literature; class discussion is emphasized.

Prerequisite: CHM210H1
Recommended Preparation: CHM220H1/ CHM222H1, ( MAT135H1, MAT136H1)/ MAT137Y1/ MAT157Y1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM416H1 - Separation Science

Hours: 24L

This course provides theoretical and practical background useful for engaging in cutting-edge chemical separations in chemistry, biology, medicine, engineering, research, and industry. The course covers general separations concepts and principles, with an emphasis on liquid chromatography and its various modes, including partition chromatography, ion chromatography, enantiomer chromatography, size exclusion chromatography, and affinity chromatography. Other topics include materials and instrumentation, gas chromatography, supercritical fluid chromatography, electrophoresis and related techniques, and a host of miscellaneous separation (e.g., TLC, FFF, CF) and extraction (e.g., LLE, SPE, SPME) modalities. Classes are supplemented with online/virtual laboratory exercises.

Prerequisite: CHM317H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM417H1 - Laboratory Instrumentation

Hours: 24L/12P

This course provides an introduction to building and using optics- and electronics-based instrumentation for laboratory research, as well as for implementing custom software control. Class topics include passive electronic components, diodes and transistors, operational amplifiers, analogue-to-digital conversion, light sources and detectors, reflectors, refractors, polarizers, diffractors, and many others. Classes are supplemented by laboratories in which students work in teams to build fluorescent detection systems for chromatography over the course of several weeks. (Lab Materials Fee: $26).

Recommended Preparation: CHM317H1
Breadth Requirements: The Physical and Mathematical Universes (5)

PHC420H1 - Application of Medicinal Chemistry to Pharmacology

Hours: 24L

This online course will build upon basic pharmacology and medicinal chemistry to make links between the basic sciences and demonstrate how basic principles can be used to improve clinical therapy. It will also include a critical evaluation of evidence for specific mechanisms and therapies. Topics covered include the effect of metabolism on drug response and factors that influence drug metabolism and kinetics; interactions of drugs with receptors, genetic differences in response, and mechanisms of tolerance; antimicrobials and antineoplastics; autocoids, antihistamines, vasopressin, anticoagulants, iron, estrogens, androgens, and the use of drugs in the perinatal period; antithyroid drugs, drugs to treat diabetes, and corticosteroids; eicosanoids, antihyperlipidemic drugs, and vitamins; drugs affecting bone metabolism, cholinergic agonists and antagonists; adrenoreceptor agonists and antagonists, agents affecting muscles and movement; opioids; CNS organization; anticonvulsants, anesthetics, and anxiolytics; antipsychotics, antidepressants, inotropic agents, antiarrhythmic drugs, diuretics; anti-inflammatory drugs, respiratory drugs, immune system organization; drugs to treat acid-peptic disorders, intestinal motility disorders, and inflammatory bowel disease; and adverse drug reactions and poisoning. An emphasis is placed on developing critical reasoning and evaluation skills to discern between standard of care and complementary therapies that have been developed in the past showing poor safety and/or efficacy, with poor regard to the scientific process. This course is restricted to Pharmaceutical Chemistry specialist program students.

Prerequisite: PHC301H1, PHC320H1, and enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Exclusion: PHM240H1
Breadth Requirements: Living Things and Their Environment (4)

PHC421H1 - Biomolecular Interactions and Thermodynamics I

Hours: 36L

This course will consider many of the topics presented in the first half in much greater detail including a rigorous examination of the interpretation of experimental data. This course is intended for students whose research or interest is in the thermodynamics of biological molecules. This course is restricted to Pharmaceutical Chemistry specialist program students.

Prerequisite: Enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Exclusion: PHM1130H
Breadth Requirements: Living Things and Their Environment (4)

CHM423H1 - Applications of Quantum Mechanics

Hours: 24L

Applications of time independent and time dependent perturbation theory to atomic and molecular problems, selection of topics from WKB approximation and the classical limit; the interaction of light with matter; elementary atomic scattering theory; molecular bonding.

Prerequisite: CHM326H1
Recommended Preparation: MAT223H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM427H1 - Statistical Mechanics

Hours: 24L

Ensemble theory in statistical mechanics. Applications, including imperfect gases and liquid theories. Introduction to non-equilibrium problems.

Prerequisite: CHM326H1, CHM328H1
Breadth Requirements: The Physical and Mathematical Universes (5)

PHC430H1 - Recent Developments in Dosage Form Design

Hours: 24L

Introduction to controlled drug delivery: Mechanisms and kinetics of controlled drug release. Fundamental theories and mathematical tools for the design of modern dosage forms. Development and applications of controlled drug delivery dosage forms. This course is restricted to Pharmaceutical Chemistry specialist program students.

Prerequisite: Enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Exclusion: PHM324H1, PHM1109H
Recommended Preparation: PHC230H1, PHC330H1, PHC340Y1
Breadth Requirements: Living Things and Their Environment (4)

PHC431H1 - Selected Topics in Drug Development

Hours: 24L

In-depth discussion of implementation of pharmaceutical sciences in drug development strategies. Students will apply fundamental principles of pharmaceutics and drug delivery to current problems in the pharmaceutical industry. This course is restricted to Pharmaceutical Chemistry specialist program students.

Prerequisite: Enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Exclusion: JFK1120H
Recommended Preparation: PHC230H1, PHC330H1, PHC340Y1
Breadth Requirements: Living Things and Their Environment (4)

PHC432H1 - Nanomedicines in Oncology

Hours: 24L

This course covers a range of topics that pertain to the development and application of nanomedicines in oncology. Students will gain an understanding of the biological barriers to drug delivery in oncology as well as the tremendous heterogeneity in cancer and the challenge this presents for treatment. The concepts of passive and active targeting of nanomedicines will be covered with critical assessment of the enhanced permeability and retention effect. A detailed overview of the most advanced nanotechnology-platforms for drug delivery (i.e., liposomes, block copolymer micelles and polymer-drug conjugates) will be provided with additional discussion of new emerging platforms. The integration of imaging in drug development and development of theranostics and therapeutic-diagnostic pairs will also be discussed. Special emphasis on critical evaluation of scientific literature and pre-clinical/clinical studies will be made throughout the course.

Prerequisite: PHC230H1, PHC330H1 and enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Breadth Requirements: Living Things and Their Environment (4)

CHM432H1 - Organometallic Chemistry and Catalysis

Hours: 24L

Structure, bonding, and reactions of organometallic compounds, with emphasis on basic mechanisms, and industrial processes. Addition, metalation, elimination, important catalytic cycles, electrophilic, and nucleophilic reactions are considered on a mechanistic basis. Topics on modern organometallic chemistry and catalysis are covered.

Prerequisite: CHM338H1
Recommended Preparation: CHM348H1
Breadth Requirements: The Physical and Mathematical Universes (5)

PHC435H1 - Pharmaceutical Data Acquisition and Analysis

Hours: 22L/26P

This course introduces students to theoretical and applied concepts in designing and implementing electronic circuitry, for the purpose of collecting and analyzing experimental data in pharmaceutics and other contexts. The course discusses introductory circuit design, with an emphasis on how common components work in scientific and pharmaceutical manufacturing instrumentation. Practical and mathematical aspects of circuit design are discussed (e.g., Ohm’s Law, voltage dividers, analog vs. digital signals). There is a heavy emphasis on programming in C++ in the Arduino IDE which will complement learning activities. Specific topics include power calculations, logic gates, capacitance, microprocessor pin functionality, switching strategies for higher powder devices (relays, transistors, MOSFETs), process control (on/off and PID controllers), and operational amplifiers. Data acquisition, smoothing, filtering, and logging strategies are also discussed. Each section has planned practical activities where circuits are built, programmed, and tested. After taking this course, students will be better equipped to build their own control circuits for undergraduate research projects and other applications.

Prerequisite: BCH210H1, CHM247H1/ CHM249H1, ( MAT135H1, MAT136H1)/ MAT137Y1, PHC340Y1 and enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM437H1 - Bioinorganic Chemistry

Hours: 24L

This course examines the use of metals in biology. Topics include naturally occurring and medicinal ligands; transport, uptake and control of concentration of metal ions; and physical methods of characterization of metal binding sites. The roles of metal ions in nature are discussed, including as structural and signaling elements in proteins, nucleic acids and DNA-binding complexes and proteins; as Lewis-acid centres in enzymes; as carriers of electrons, atoms and groups in redox proteins and enzymes; and as sources of biominerals; as radiopharmaceuticals.

Prerequisite: CHM236H1 + CHM237H1
Exclusion: CHM333H5, CHMD69H3
Recommended Preparation: CHM338H1(strongly recommended), CHM347H1/ CHM379H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM440H1 - The Synthesis of Modern Pharmaceutical Agents

Hours: 24L

This course provides an overview of reactions and synthetic strategies that are being used at different stages of the drug development process. Using representative examples from the literature, we will concentrate on synthesis of complex heterocyclic compounds.

Prerequisite: CHM342H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM441H1 - Spectroscopic Analysis in Organic Chemistry

Hours: 24L/20P

Structure and stereochemistry determination using modern spectroscopic techniques. Several techniques are discussed but particular emphasis is given to NMR (1H and 13C NMR) and mass spectrometry. The approach taken emphasizes applications of these spectroscopic methods to organic problems. Students are trained to run their own spectra (IR, UV, NMR, GC-MS). (Lab Materials Fee: $26).

Prerequisite: CHM249H1, CHM343H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM443H1 - Physical Organic Chemistry

Hours: 24L

Noncovalent binding forces, solutions, and molecular recognition. Electronic structure theory and computational techniques. Reaction mechanisms: experimental probes and reactive intermediates, including carbenes and radicals. Photophysics and photochemistry of organic compounds.

Prerequisite: CHM220H1/ CHM222H1, CHM348H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM447H1 - Bio-organic Chemistry

Hours: 24L

Mechanisms in biochemical systems: Examples of biological catalysis are considered in terms of chemical mechanisms and their extensions, overcoming barriers catalytic groups in active sites, stereochemical applications, energy transfer, kinetic patterns, inhibitors, drug design, cofactors, ribozymes, and proteosomes. Related current issues are noted and discussed. The format includes class material integrated with student discussions.

Prerequisite: CHM347H1, CHM348H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM455H1 - Advanced Materials Chemistry

Previous Course Number: CHM434H1

Hours: 24L

A comprehensive investigation of synthetic methods for preparing diverse classes of inorganic materials with properties intentionally tailored for a particular use. Begins with a primer on solid-state materials and electronic band description of solids followed by a survey of archetypical solids that have had a dramatic influence on the materials world, some new developments in materials chemistry and a look at perceived future developments in materials research and technology. Strategies for synthesizing many different classes of materials with intentionally designed structures and compositions, textures and morphologies are then explored in detail emphasizing how to control the relations between structure and property of materials and ultimately function and utility. A number of contemporary issues in materials research are critically evaluated to appreciate recent highlights in the field of materials chemistry - an emerging sub-discipline of chemistry.

Prerequisite: CHM325H1/ CHM355H1, CHM338H1
Exclusion: CHM434H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM456H1 - Organic Materials Chemistry

Previous Course Number: CHM446H1

Hours: 24L

This course covers design, synthesis, characterization and application of organic materials. Emphasis is placed on classic examples of organic materials including semiconducting polymers, molecular devices, self-assembled systems, and bioconjugates, as well as recent advances from the literature.

Prerequisite: CHM220H1/ CHM222H1, CHM247H1/ CHM249H1
Exclusion: CHM446H1
Recommended Preparation: CHM355H1, CHM342H1/ CHM343H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM457H1 - Polymer Chemistry

Previous Course Number: CHM426H1

Hours: 24L/12T

Scope of polymer chemistry. Classification of polymers. Synthesis and characterization. Polymers in solution. Thermodynamics of polymer solutions and blends, Flory-Huggins theory. Polymers in the solid state. Crystalline and amorphous polymers. Glass transition and melting temperature. Mechanical properties. Polymers as advanced materials.

Prerequisite: CHM220H1/ CHM222H1, CHM247H1/ CHM249H1
Exclusion: CHM426H1
Recommended Preparation: CHM355H1
Breadth Requirements: The Physical and Mathematical Universes (5)

CHM458H1 - Soft Materials for Life, Energy, and the Environment

Hours: 24L

In the framework of a dry lab, students will analyze and interpret characterization data, extending their existing knowledge of chemical fundamentals and experimental techniques to polymeric systems. Through a combination of classes, dynamic group collaborations, and self-paced assignments, students will actively engage with peers to understand course materials (including published literature), explore how polymer innovations are commercialized, and develop a toolkit for leveraging instrumentation to investigate hypotheses in research.

Prerequisite: CHM247H1/ CHM249H1/ MSE245H1, CHM220H1/ CHM222H1/ CHM223H1/ APS110H1
Recommended Preparation: CHM355H1, CHM342H1/ CHM343H1, CHM426H1/ CHM457H1
Breadth Requirements: The Physical and Mathematical Universes (5)

PHC460H1 - Fundamentals of Drug Discovery

Hours: 24L

Lectures by scientists from academia and industry, and student seminars based on journal articles dealing with strategies for discovering new drugs for therapy and diagnosis. This course is restricted to Pharmaceutical Chemistry specialist program students.

Prerequisite: BIO120H1, BIO130H1, PHC301H1 and enrolled as a Year 4 student in the Pharmaceutical Chemistry program.
Breadth Requirements: Living Things and Their Environment (4)

PHC462H1 - Clinical Drug Development

Hours: 24L

This course is designed to broaden student’s understanding of the development and licensing of new drugs and how scientific principles, ethics, governmental regulations and commercial considerations are coordinated for designing clinical trails. The format involves lectures, group discussion and student presentations. This course is restricted to Pharmaceutical Chemistry specialist program students.

Prerequisite: PHC230H1, PHC301H1, PHC340Y1 and enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Exclusion: JFK1120H
Breadth Requirements: Society and its Institutions (3)

PHC470H1 - Global Pharmaceutical Policy

Hours: 24L/2T

This course is designed for students who are interested in the critical analysis of global health policy and the interrelationship between global and domestic policy issues. The course will introduce students generally to the basic concepts and issues in global health with a particular focus on pharmaceutical policy. We will address key issues in health and discuss core institutional and transnational actors, how governments in different jurisdictions manage public health responsibilities, the tension between economic imperatives and health objectives, global obligations, and pressure from special interest groups. More narrowly, we will analyze a breadth of complex policies questions. Examples include: the research and development global divide, policial issues influences on pharmaceutical policy, how global commitments, such as membership in the World Trade Organization, conflict with or correspond to domestic policy directions and national sovereignty. Guest speakers will lead some sessions. This course will consist of lectures, guest discussions, case studies and student-led presentations. This is restricted to students in the Pharmaceutical Chemistry specialist program.

Prerequisite: Enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Exclusion: PHM320H1, PHM1124H
Breadth Requirements: Society and its Institutions (3)

CHM479H1 - Biological Chemistry

Hours: 24L

An in depth examination of biological systems at the molecular level. Several complex, multi-component molecular machines with a central role in life will be examined. For each system studied, the focus will be on understanding the chemical mechanisms that underlie the biological activities, and how these processes fit into a cellular context.

Prerequisite: BCH210H1/ BCH242Y1, CHM347H1
Breadth Requirements: The Physical and Mathematical Universes (5)

PHC489Y1 - Pharmaceutical Chemistry Research

Hours: 165P

This course will provide research experience under the supervision of a Departmental staff member. The goal is to deepen the student’s understanding of the scientific basis and practical techniques relevant to modern pharmaceutical development. This course is restricted to Pharmaceutical Chemistry specialist program students. Not eligible for CR/NCR option.

Prerequisite: Permission from the Course Coordinator and enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Breadth Requirements: Living Things and Their Environment (4)

CHM499Y1 - Introduction to Chemistry Research

Hours: 240P/16S

An experimental or theoretical research problem under the supervision of a teaching faculty or research faculty member in the Department of Chemistry. Five mandatory 90-minute professional development workshops cover aspects of academic writing, poster presentations, reading scientific literature, and job applications/interviews. Each student is required to attend a total of six one-hour research colloquia during the Fall and Winter Sessions. Applications for enrolment should be made to the Department in the preceding Winter Session: the application form is available on the Department of Chemistry website. Only students being admitted are required to contact chemistry faculty to discuss available research projects. Projects are in the areas of environmental, analytical, physical, inorganic, materials, polymer, organic and biological chemistry. Not eligible for CR/NCR option.

Prerequisite: Permission of the department. Minimum cGPA of 3.0 in CHM program courses. Research positions are limited. Students with strong background on courses in the sub-discipline of research interest will be given preference. Attendance at a mandatory safety orientation training session held during the first week of September.
Exclusion: CHM489Y5, CHMD90Y3, MSE498Y1, PHC489Y1
Breadth Requirements: The Physical and Mathematical Universes (5)

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