Therapies that enhance, or suppress, the body’s immune response have proven remarkably efficient for the treatment of human diseases such as cancer, autoimmunity and chronic inflammation. Some of these therapies, such as the so-called checkpoint inhibitors and CAR-T cell therapies have recently leaped from bench to bedside. This course will cover the fundamental immune principles at play, how they were discovered, as well as the existing and future immune therapies to treat these diseases.