Principles and methods of analyzing and predicting organic chemical reactivity: advanced stereochemistry, conformational analysis, molecular orbitals, reaction kinetics, isotope effects, linear free energy relationships, orbital transformations, systematization of mechanisms. The laboratory section is used to illustrate the operation of the principles, including examples of data acquisition for mechanistic analysis and theoretical computations. Regular original reports on methods and outcomes are an important part of the laboratory. (Lab Materials Fee: $25).