This advanced course aims to provide students with current, in-depth knowledge of the genetics of specific human diseases, including single gene (e.g., Huntington disease), multifactorial (e.g. Alzheimer’s disease), and non-Mendelian (e.g. mitochondrial DNA-related disease) disorders, and how the use of genetics to elucidate disease mechanisms can lead to treatments and personalized medicine in order to improve healthcare.