Pharmaceutical Chemistry


Collaborative Program of the Faculty of Arts & Science and the Leslie Dan Faculty of Pharmacy

Introduction

Pharmaceutical Chemistry combines knowledge of the biological, medical, and physical sciences in the study of drug therapy. The emphasis is on the chemical nature of the reactions and interactions involved in drug therapy. The students will receive a solid background in the facets of chemistry the most relevant to drugs: physical, organic, and analytical chemistry. They will also learn the fundamental aspects of the synthesis, manufacture, use, and mode of action of drugs.

Undergraduate Office – General Enquiries

Nicole Treston, (416-978-6033), chem.undergrad@utoronto.ca

Program Director: Dr. David Dubins, (416-976-5303), d.dubins@utoronto.ca

 

Regarding Pharmaceutical Chemistry Programs

Pharmaceutical Chemistry combines knowledge of the biological, medical and physical sciences in the study of the scientific aspect of drug therapy. The emphasis is on the chemical nature of the reactions and interactions involved in drug therapy.

This program is offered jointly by the Leslie Dan Faculty of Pharmacy and the Faculty of Arts and Science. Students in the Pharmaceutical Chemistry Specialist program will receive a solid background in physical, organic and analytical chemistry, and will also learn the fundamental aspects of the synthesis, manufacture, use, and mode of action of drugs. The fourth-year project course gives students direct involvement in research.

Arts & Science Internship Program

The new Arts & Science Internship Program (ASIP) stream is available to students entering their second year of study in Fall 2021 and enrolled in the Pharmaceutical Chemistry Specialist.

  • Enrolment is limited and requires a supplemental application. Students enrolled in the ASIP stream will be required to complete mandatory Professional Development programming plus a minimum of 12 and maximum of 20 months of paid, full-time work experience. The time to degree completion for students enrolled in ASIP will normally be 5 years. There is an additional cost to participate in the ASIP stream.
     
  • Students will typically be admitted to the ASIP stream for the Fall term of Year 2 of study, however starting in Fall 2022, in exceptional circumstances students, including transfer students, who enrolled in an eligible program in the Summer after Year 2 can be admitted to the ASIP stream for the Fall of Year 3. Year 3 entry into the program requires prior approval of the Associate Chair, Undergraduate or their designate and the Experiential Learning & Outreach Support (ELOS) Office.
     
  • Further details about ASIP, including eligibility requirements and application procedures, can be found here. Students may also visit the ASIP webpage or contact the ELOS office at asip@utoronto.ca.

Note Regarding the Professional Experience Year Program (PEY)

January 2022 was the last opportunity for Faculty of Arts & Science students to register for the PEY Co-op. Students in Year 3 in the Fall/Winter 2021-2022 session were the last group of Faculty of Arts & Science students eligible to participate in PEY Co-op. Students starting Year 2 in Fall 2021 or later are only eligible to participate in the Arts & Science Internship Program stream.

Pharmaceutical Chemistry Programs

Pharmaceutical Chemistry Specialist (Science Program) - ASSPE1211

Consult Professor D. Dubins, Faculty of Pharmacy

The Pharmaceutical Chemistry Specialist Program combines knowledge of the biological, medical, and physical sciences in the study of the scientific aspects of drug therapy, with an emphasis placed on the chemical nature of the reactions and interactions involved in drug therapy. The program is offered jointly by the Department of Chemistry and the Leslie Dan Faculty of Pharmacy at the University of Toronto. Students in the Pharmaceutical Chemistry Specialist program will receive a solid background and training in physical, organic, and analytical chemistry, and will also learn the fundamental aspects of the synthesis, manufacture, use, and mode of action of drugs. This program provides excellent preparation for future work in the pharmaceutical industry and is accredited by Canadian Society for Chemistry,

Enrolment Requirements:

This is a limited enrolment program. Students must have completed 4.0 credits and meet the requirements listed below to enrol.

Variable Minimum Grade Average
A minimum grade average is needed for entry, and this minimum changes each year depending on available spaces and the number of applicants. The following courses must be completed:

BIO120H1 and BIO130H1
• ( CHM135H1 and CHM136H1)/ CHM151Y1
• ( PHY131H1 and PHY132H1)/( PHY151H1 and PHY152H1)

To ensure that students admitted to the program will be successful, applicants with a final grade lower than 60%, or a grade average lower than 70% will not be considered for admission. Please note that obtaining this minimum final grade or minimum grade average does not guarantee admission to the program.

Arts & Science Internship Program

Students in this program have the option to request enrolment in the Arts & Science Internship Program (ASIP) stream. Students can apply for the ASIP stream after Year 1 (Year 2 entry) or after Year 2 (Year 3 entry). Full details about ASIP, including student eligibility, selection and enrolment, are available in the ASIP section of the Arts & Science Academic Calendar. Please note that space is more limited for Year 3 entry and students applying for Year 3 entry must have been admitted to the Pharmaceutical Chemistry Specialist in the Summer after Year 2.

Completion Requirements:

(13.0 credits, including 1.0 credit from 400-level courses)

NOTE: Some of the courses listed below may have prerequisites.

First Year:

  1. BIO120H1, BIO130H1
  2. ( CHM135H1 and CHM136H1)/ CHM151Y1
  3. ( PHY131H1 and PHY132H1)/ ( PHY151H1 and PHY152H1)

Second Year:

  1. BCH210H1
  2. BIO230H1
  3. CHM220H1/​ CHM222H1, CHM223H1, ( CHM249H1 strongly recommended/ CHM247H1)
  4. PCL201H1
  5. PHC230H1

Third Year:

  1. CHM217H1
  2. PHC300H1, PHC301H1, PHC320H1, PHC330H1, PHC340Y1

Fourth Year:

  1. PHC489Y1/​ CHM499Y1
  2. 2.0 credits from: CHM317H1, CHM342H1, CHM347H1, CHM379H1, CHM410H1, CHM414H1, CHM417H1, CHM427H1, CHM440H1, JPM300H1, JPM400Y1, PCL362H1, PCL386H1, PHC331H1, PHC401H1, PHC420H1, PHC421H1, PHC430H1, PHC431H1, PHC432H1, PHC435H1, PHC460H1, PHC462H1, PHC470H1, PSL300H1, PSL301H1

Note that not all of the 400-level PHC courses are offered every academic year.



Pharmaceutical Chemistry Courses

PHC230H1 - Pharmaceutics 1

Hours: 36L/12T

An introduction to the key concepts in the design, manufacture, and use of efficacious dosage forms. The course covers the characteristics of different delivery routes.

Prerequisite: ( CHM135H1 and CHM136H1)/ CHM151Y1; CHM220H1/ CHM222H1
Exclusion: PHM141H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PHC300H1 - Molecular Pharmacology 1

Hours: 24L/12T

Structural and mechanistic determinants of drug action at the molecular level. Topics include the physical-chemical properties of drugs per se as they relate to therapeutic intervention and the biophysical and biochemical properties of enzymes and nucleic acids that underlie and are affected by their interactions with drugs.

Prerequisite: ( CHM135H1, CHM136H1)/ CHM151Y1; CHM220H1/ CHM222H1
Exclusion: PCL302H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PHC301H1 - Molecular Pharmacology 2

Hours: 36L/12T

Structural and mechanistic determinants of drug action via macromolecules that effect cellular signalling. Neurohumoral receptors and other signalling proteins are grouped according to their structure and mechanism of action. Native properties and their modulation by drugs are discussed in the context of basic principles of molecular pharmacology.

Prerequisite: ( CHM135H1, CHM136H1)/ CHM151Y1; CHM220H1/ CHM222H1; BCH210H1
Exclusion: PCL302H1, PHM140H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PHC320H1 - Medicinal Chemistry

Hours: 36L

Modern discovery and synthesis of antibiotics, antineoplastics, antiviral and other therapeutic agents.

Prerequisite: BCH210H1, CHM247H1/ CHM249H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PHC330H1 - Pharmaceutics 2

Hours: 36L/12T

This course presents a detailed examination of the material properties of pharmaceuticals and the role of cellular processes in delivery of a drug to its site of action.

Prerequisite: ( CHM135H1, CHM136H1)/ CHM151Y1; CHM220H1/ CHM222H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PHC331H1 - Establishing the Bioequivalence of Pharmaceutical Products

Hours: 48L

Introduction to human clinical trial design for the demonstration of pharmaceutical bioequivalence of drug products. Students will learn the principles underlying the regulations and methods employed in bioequivalence studies.

Prerequisite: BCH210H1, CHM247H1/ CHM249H1, ( MAT135H1, MAT136H1)/ MAT137Y1, PHC230H1, PHC330H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PHC340Y1 - Pharmaceutical Chemistry Laboratory

Hours: 24L/96P

The scientific basis and practical techniques relevant to modern pharmaceutical development. This course is restricted to Pharmaceutical Chemistry Specialist program students.

Prerequisite: CHM247H1/ CHM249H1; ( CHM220H1/ CHM222H1), CHM223H1; BCH210H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PHC401H1 - Drug Transport across Biological Membranes

Hours: 24L

The goal of this course is to provide students with knowledge of the molecular processes involved in drug transport across biological cell membranes with emphasis on their physiological and clinical significance. This course is restricted to Pharmaceutical Chemistry Specialist program students.

Prerequisite: PHC301H1, and enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Corequisite: PHC300H1
Exclusion: JFK1122H
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PHC420H1 - Application of Medicinal Chemistry to Pharmacology

Hours: 24L

This course shows students the links between basic science and the drugs used therapeutically to treat clinical problems. This course is restricted to Pharmaceutical Chemistry specialist program students.

Prerequisite: PHC301H1, PHC320H1, and enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Exclusion: PHM240H1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PHC421H1 - Biomolecular Interactions and Thermodynamics I

Hours: 36L

This course will consider many of the topics presented in the first half in much greater detail including a rigorous examination of the interpretation of experimental data. This course is intended for students whose research or interest is in the thermodynamics of biological molecules. This course is restricted to Pharmaceutical Chemistry specialist program students.

Prerequisite: Enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Exclusion: PHM1130H
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PHC430H1 - Recent Developments in Dosage Form Design

Hours: 24L

Introduction to controlled drug delivery: Mechanisms and kinetics of controlled drug release. Fundamental theories and mathematical tools for the design of modern dosage forms. Development and applications of controlled drug delivery dosage forms. This course is restricted to Pharmaceutical Chemistry specialist program students.

Prerequisite: Enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Exclusion: PHM324H1, PHM1109H
Recommended Preparation: PHC230H1, PHC330H1, PHC340Y1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PHC431H1 - Selected Topics in Drug Development

Hours: 24L

In-depth discussion of implementation of pharmaceutical sciences in drug development strategies. Students will apply fundamental principles of pharmaceutics and drug delivery to current problems in the pharmaceutical industry. This course is restricted to Pharmaceutical Chemistry specialist program students.

Prerequisite: Enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Exclusion: JFK1120H
Recommended Preparation: PHC230H1, PHC330H1, PHC340Y1
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PHC432H1 - Nanomedicines in Oncology

Hours: 24L

This course covers a range of topics that pertain to the development and application of nanomedicines in oncology. Students will gain an understanding of the biological barriers to drug delivery in oncology as well as the tremendous heterogeneity in cancer and the challenge this presents for treatment. The concepts of passive and active targeting of nanomedicines will be covered with critical assessment of the enhanced permeability and retention effect. A detailed overview of the most advanced nanotechnology-platforms for drug delivery (i.e., liposomes, block copolymer micelles and polymer-drug conjugates) will be provided with additional discussion of new emerging platforms. The integration of imaging in drug development and development of theranostics and therapeutic-diagnostic pairs will also be discussed. Special emphasis on critical evaluation of scientific literature and pre-clinical/clinical studies will be made throughout the course.

Prerequisite: PHC230H1, PHC330H1 and enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PHC435H1 - Pharmaceutical Data Acquisition and Analysis

Hours: 22L/26P

Application and development of devices for the purpose of collecting and analyzing experimental data in pharmaceutical development and manufacture.

Prerequisite: BCH210H1, CHM247H1/ CHM249H1, ( MAT135H1, MAT136H1)/ MAT137Y1, PHC340Y1 and enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Distribution Requirements: Science
Breadth Requirements: The Physical and Mathematical Universes (5)

PHC460H1 - Fundamentals of Drug Discovery

Hours: 24L

Lectures by scientists from academia and industry, and student seminars based on journal articles dealing with strategies for discovering new drugs for therapy and diagnosis. This course is restricted to Pharmaceutical Chemistry specialist program students.

Prerequisite: BIO120H1, BIO130H1, PHC301H1 and enrolled as a Year 4 student in the Pharmaceutical Chemistry program.
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

PHC462H1 - Clinical Drug Development

Hours: 24L

This course is designed to broaden student’s understanding of the development and licensing of new drugs and how scientific principles, ethics, governmental regulations and commercial considerations are coordinated for designing clinical trails. The format involves lectures, group discussion and student presentations. This course is restricted to Pharmaceutical Chemistry specialist program students.

Prerequisite: PHC230H1, PHC301H1, PHC340Y1 and enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Exclusion: JFK1120H
Distribution Requirements: Science
Breadth Requirements: Society and its Institutions (3)

PHC470H1 - Global Pharmaceutical Policy

Hours: 24L/2T

This course is designed for students who are interested in the critical analysis of global health policy and the interrelationship between global and domestic policy issues. The course will introduce students generally to the basic concepts and issues in global health with a particular focus on pharmaceutical policy. We will address key issues in health and discuss core institutional and transnational actors, how governments in different jurisdictions manage public health responsibilities, the tension between economic imperatives and health objectives, global obligations, and pressure from special interest groups. More narrowly, we will analyze a breadth of complex policies questions. Examples include: the research and development global divide, policial issues influences on pharmaceutical policy, how global commitments, such as membership in the World Trade Organization, conflict with or correspond to domestic policy directions and national sovereignty. Guest speakers will lead some sessions. This course will consist of lectures, guest discussions, case studies and student-led presentations. This is restricted to students in the Pharmaceutical Chemistry specialist program.

Prerequisite: Enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Exclusion: PHM320H1, PHM1124H
Breadth Requirements: Society and its Institutions (3)

PHC489Y1 - Pharmaceutical Chemistry Research

Hours: 165P

This course will provide research experience under the supervision of a Departmental staff member. The goal is to deepen the student’s understanding of the scientific basis and practical techniques relevant to modern pharmaceutical development. This course is restricted to Pharmaceutical Chemistry specialist program students. Not eligible for CR/NCR option.

Prerequisite: Permission from the Course Coordinator and enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.
Distribution Requirements: Science
Breadth Requirements: Living Things and Their Environment (4)

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